Amyloidosis is a disease characterized by protein deposition in tissues and organs, most commonly the kidney, heart, liver, nervous system, and gastrointestinal tract.1 Extracellular fibrils form β-pleated sheets disrupting organ function. Over 20 different proteins have been observed in amyloidosis, but all forms are identified by Congo red stain and a green birefringence pattern under polarized light.
Fibril deposits confined to a single organ system define localized amyloidosis. Respiratory, urogenital, and gastrointestinal tracts as well as the skin are the most commonly are the most commonly affected organs. Laryngeal amyloid is relatively rare, with the vocal cords and ventricles being the most affected sites.2 We present herein 3 cases of laryngeal amyloidosis, review the current literature, and provide recommendations regarding the evaluation, treatment, and follow-up of patients with laryngeal amyloidosis.