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Clinical Note |

IgG4-Sclerosing Pseudotumor of the Trachea:  A Case Report and Review of the Literature

Jagdeep Singh Virk, MA(Cantab), MRCS, DOHNS; Constantine Stamatoglou, BSc, MRCS, DOHNS; Ivor Kwame, BSc, MRCS, DOHNS; Alan Salama, MBBS, PhD; Ann Sandison, FRCPath; Gurpreet Sandhu, MD, FRCS, FRCS(ORL-HNS)
Arch Otolaryngol Head Neck Surg. 2012;138(9):864-866. doi:10.1001/archoto.2012.1821.
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Immunoglobulin G (IgG) molecules are a family of glycoproteins involved predominantly in the anamnestic or secondary immune response and comprise 4 subclasses (IgG1-4) that vary in their capacity to trigger effector functions and their serum prevalence, with IgG4 being the least abundant.1 During autoimmune disease processes, the normally protective antimicrobial function of these molecules is targeted to healthy tissues, often with deleterious consequences.

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Figure 1. Intraoperative image of larynx before reconstruction.

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Figure 2. Intraoperative image of larynx and airway after laryngotracheal reconstruction.




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