Submitted for Publication: April 3, 2012; final revision received July 11, 2012; accepted August 15, 2012.
Author Contributions: All authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Daniel, Al-Zahid, Rahman, McLaren, Cox, Qutachi, Fortnum, Fergie, Shakesheff, Birchall, and Bayston. Acquisition of data: Daniel, Chessman, and Richards. Analysis and interpretation of data: Daniel, Chessman, Ashraf, Fortnum, Birchall, and Bayston. Drafting of the manuscript: Daniel and Bayston. Critical revision of the manuscript for important intellectual content: Daniel, Chessman, Al-Zahid, Richards, Rahman, Ashraf, McLaren, Cox, Qutachi, Fortnum, Fergie, Shakesheff, Birchall, and Bayston. Statistical analysis: Daniel and Chessman. Obtained funding: Daniel, Al-Zahid, Fortnum, and Birchall. Administrative, technical, and material support: Daniel, Al-Zahid, Richards, Rahman, Ashraf, McLaren, Cox, Qutachi, and Fergie. Study supervision: Daniel, Fortnum, Fergie, Shakesheff, Birchall, and Bayston.
Financial Disclosure: None reported.
Funding/Support: This study was supported in part by the Medical Research Council, Midland Institute of Otolaryngology, National Biomedical Research Unit in Hearing, Royal Society of Medicine, and Sir Samuel Scott of Yews Trust.
Previous Presentations: This article was presented at the American Society of Pediatric Otolaryngology 2012 Annual Meeting; April 20, 2012; San Diego, California; Recent Advances in Otitis Media; June 6, 2011; New Orleans, Louisiana; Otorhinolaryngologic Research Society; March 18, 2011; London, England; and Royal Society of Medicine Otology Section; March 4, 2011; London, England.