Submitted for Publication: July 6, 2012; final revision received August 23, 2012; accepted September 18, 2012.
Published Online: November 19, 2012. doi:10.1001/jamaoto.2013.853
Author Contributions: Dr Duffy had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Shuman, Terrell, Wolf, Chepeha, and Duffy. Acquisition of data: Terrell, Light, Wolf, Chepeha, McLean, Ghanem, and Duffy. Analysis and interpretation of data: Shuman, Terrell, Light, Wolf, Bradford, Chepeha, Jiang, and Duffy. Drafting of the manuscript: Shuman, Light, Wolf, Chepeha, Jiang, and Duffy. Critical revision of the manuscript for important intellectual content: Shuman, Terrell, Light, Bradford, Chepeha, McLean, Ghanem, and Duffy. Statistical analysis: Shuman, Light, and Jiang. Obtained funding: Terrell, Wolf, and Duffy. Administrative, technical, and material support: Terrell, Wolf, Chepeha, and Duffy. Study supervision: Terrell, Bradford, and Duffy.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by the National Institutes of Health through the University of Michigan's Head and Neck Specialized Program of Research Excellence (SPORE) grant (P50 CA097248) titled “The Molecular Basis of Head and Neck Cancer: Biology, Treatment and Prevention.”
Previous Presentation: This study was presented at the American Head and Neck Society meeting; July 24, 2012; Toronto, Ontario, Canada.
Additional Contributions: We would like to express our gratitude to the many patients with head and neck cancer who participated in this study. Many thanks to all clinicians, researchers, and ancillary staff members associated with the care and study of the patients involved with the University of Michigan Head and Neck Specialized Program of Research Excellence, including Tom Carey, PhD; Theodoros Teknos, MD; Nisha D’Silva, DDS, PhD; Avraham Eisbruch, MD; Theodore Lawrence, MD, PhD; Sofia Merajver, MD, PhD; Jacques Nor, DDS, PhD; Mukesh Nyati, PhD; Laura Rozek, PhD; Shaomeng Wang, PhD; and Frank Worden, MD.