Submitted for Publication: July 17, 2012; final revision received October 16, 2012; accepted November 20, 2012.
Author Contributions: Drs S. M. Cohen, Mukerji, and Shnayder had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Mukerji, Durham, Forrest, Cai, and Shnayder. Acquisition of data: S. M. Cohen, Rockefeller, and Mukerji. Analysis and interpretation of data: S. M. Cohen, Rockefeller, M. S. Cohen, and Shnayder. Drafting of the manuscript: S. M. Cohen. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: S. M. Cohen, Rockefeller, and M. S. Cohen. Obtained funding: Shnayder. Administrative, technical, and material support: Rockefeller, Mukerji, Forrest, and Cai. Study supervision: S. M. Cohen, Mukerji, M. S. Cohen, and Shnayder.
Conflict of Interest Disclosures: Drs Forrest and Cai have proprietary interest in patent 8 088 412 on the use of HA for drug delivery and have interest in a company that has licensed this technology. Dr M. S. Cohen is CEO of Nanopharm LLC, in which he has ownership interest but has received no financial revenues to date. He also reports having received a Susan G. Komen Foundation Career Catalyst Grant.
Funding/Support: The MDA-1986 cells were a gift from Jeffrey Myers, MD, PhD, of The University of Texas, MD Anderson Cancer Center, Houston. This work was completed through research grant–funding support from the American Academy of Otolaryngology–Head and Neck Surgery/American Head and Neck Society Centralized Otolaryngology Research Efforts (CORE) Grant Program Young Investigator Award (principal investigator [PI], Dr Shnayder; coinvestigators, Drs Durham, Forrest, and M. S. Cohen), Susan G. Komen Foundation Career Catalyst Grant KG090481 (PI, Dr M. S. Cohen), grant RSG-08-133-01-CDD from the American Cancer Society (PI, Dr Forrest; coinvestigator, Dr M. S. Cohen), grant NFP51505 (RGS-08-133-01-CDD) to The University of Kansas Center for Research from the American Cancer Society (PI, Dr Forrest; coinvestigator, Dr M. S. Cohen), and research support from the Departments of Surgery and Head and Neck Surgery, The University of Kansas, Kansas City.