Submitted for Publication: April 24, 2013; final revision received June 24, 2013; accepted June 28, 2013.
Study concept and design: Muskett, Griffith.
Acquisition of data: Chattaraj, Reimold, Muskett, Shmukler, Chien, Madeo, Pryor, Zalewski, Butman, Brewer, Kenna.
Analysis and interpretation of data: Chattaraj, Muskett, Chien, Alper, Griffith.
Drafting of the manuscript: Chattaraj, Muskett, Pryor, Alper, Griffith.
Critical revision of the manuscript for important intellectual content: Reimold, Muskett, Shmukler, Chien, Madeo, Pryor, Zalewski, Butman, Brewer, Kenna.
Statistical analysis: Muskett, Pryor.
Obtained Funding: Reimold, Alper, Griffith.
Administrative, technical, and material support: Chattaraj, Reimold, Muskett, Shmukler, Madeo, Pryor, Zalewski, Brewer, Griffith.
Study supervision: Chien, Griffith.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by intramural research funds Z01-DC-000082 (Dr Chien) and Z01-DC-000060 and Z01-DC-000064 (Dr Griffith), by grants R01 DK43495 and R30 DK34854 (The Harvard Digestive Diseases Center) (Dr Alper) from the National Institutes of Health, and by the Robert Bosch Foundation (Dr Reinmold).
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Thomas Shawker, MD, provided ultrasonographic evaluations of the thyroid, and Dennis Drayna, PhD, and Tom Friedman, PhD, provided critical comments and reviewed the manuscript.
Correction: This article was corrected on December 1, 2014, to fix typographical errors in Figure 3.