Submitted for Publication: April 3, 2013; final revision received July 16, 2013; accepted July 23, 2013.
Published Online: September 12, 2013. doi:10.1001/jamaoto.2013.4690.
Study concept and design: Tran, Reid, Hamood.
Acquisition of data: Wang, Hanes.
Analysis and interpretation of data: Hanes, Cordero, Marchbanks, Reid, Hamood.
Drafting of the manuscript: Wang, Tran, Colmer-Hamood, Hamood.
Critical revision of the manuscript for important intellectual content: Hanes, Cordero, Marchbanks, Reid, Colmer-Hamood, Hamood.
Statistical analysis: Wang, Tran, Colmer-Hamood.
Obtained funding: Reid.
Administrative, technical, or material support: Hanes, Cordero, Marchbanks.
Study supervision: Reid, Hamood.
Conflict of Interest Disclosures: None reported.
Funding /Support: This study was supported by a National Institutes of Health grant 1R41DC010963. In addition, Mr Wang received an academic scholarship from the Achievement Rewards for College Scientists Foundation.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentation: This study was presented at the 2013 American Society of Pediatric Otolaryngology Meeting; April 27, 2013; Arlington, Virginia.
Additional Contributions: TheSa-AH133 with pCM11 and NTHi-86-028NP/pRMS2211 were generous gifts from Alexander Horswill, PhD (University of Iowa Carver College of Medicine, Iowa City), and Lauren Bakaletz, PhD (Nationwide Children’s Hospital, Columbus, Ohio), respectively. Illustrations of Donaldson-type tympanostomy tubes were kindly provided by Medtronic Inc.