Submitted for Publication: May 17, 2013; final revision received July 22, 2013; accepted August 15, 2013.
Published Online: October 31, 2013. doi:10.1001/jamaoto.2013.5460.
Study concept and design: Walline, McHugh, Bellile, Moyer, Prince, Chepeha, Eisbruch, Carey.
Acquisition of data: Walline, Komarck, McHugh, Byrd, Hauff, Graham, Wolf, Worden, Stenmark, Carey.
Analysis and interpretation of data: Walline, McHugh, Spector, Hauff, Bellile, Prince, Wolf, Stenmark, Bradford, Carey.
Drafting of the manuscript: Walline, Carey.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Walline, Hauff, Bellile.
Obtained funding: Walline, Byrd, Moyer, Wolf, Chepeha, Carey.
Administrative, technical, or material support: Walline, Komarck, McHugh, Byrd, Spector, Graham, Stenmark, Carey.
Study supervision: Spector, Prince, Eisbruch, Bradford, Carey.
Conflict of Interest Disclosures: None reported.
Funding/Support: The investigators were supported by grant P50 CA097248 from the National Institutes of Health–National Cancer Institute (NIH-NCI) Head and Neck SPORE (Specialized Programs of Research Excellence), grant R01 DE019126 from the NIH–National Institute of Dental and Craniofacial Research (NIDCR), Cancer Biology Training Grant NIH-NCI T32 CA09676, and the University of Michigan Rackham Graduate School Eleanor Lewis Scholarship. In addition, Cancer Center Support Grant P30 CA46592 from the NIH-NCI supported the investigators who performed collection, management, analysis, and interpretation of the data and grant P30 DC05188 from the NIH-NIDCD funded infrastructure support.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We acknowledge all of the physicians, nurses, and staff associated with the SPORE who supported this work. The authors thank the staff and director of the University of Michigan DNA Sequencing Core for providing access to equipment and sequencing expertise. We are also grateful to the patients who generously participate in our studies and provide us permission to examine their tissues.
Correction: This article was corrected to fix errors in data on October 31, 2013.