0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Original Investigation |

Second Cancer Incidence and Risk Factors in Patients With Salivary Gland Cancers

Minsu Kwon, MD1; Jong-Ik Lee, MD1; Jong-Lyel Roh, MD1; Kyung-Ja Cho, MD2; Jaewon Choe, MD3; Seung-Ho Choi, MD1; Soon Yuhl Nam, MD1; Sang Yoon Kim, MD1,4
[+] Author Affiliations
1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
3Health Screening & Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
4Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea
JAMA Otolaryngol Head Neck Surg. 2014;140(2):118-123. doi:10.1001/jamaoto.2013.6149.
Text Size: A A A
Published online

Importance  Second primary cancers (SPCs) are common in patients with head and neck squamous cell carcinoma, while the incidence and risk factors of SPC in patients with salivary gland cancers (SGCs) are largely unknown. This study aimed to examine the incidence of and risk factors for SPC in patients with SGC.

Objective  To report the risk factors and incidence of SPC in patients with SGC and compare them with the values of newly developed cancers (NDCs) in a healthy population.

Design, Setting, and Participants  A retrospective case-control study conducted at a university teaching hospital. The study population comprised 184 patients with SGC, without a history of cancer, who were treated between 2000 and 2010 and followed up for at least 2 years, and 200 healthy individuals (control group) who underwent medical examinations in health promotion programs during the same period.

Interventions  All individuals received the diagnostic scrutiny including endoscopic and radiological examinations at initial staging and at follow-up. Individuals suspected of having SPC or NDC underwent histological confirmation.

Main Outcomes and Measures  Risk factors of SPC development and cumulative incidence of SPC (or NDC) in each group.

Results  The cumulative 2-, 5-, and 10-year rates of SPC were 4.4%, 8.3%, and 12.4%, respectively, and those of NDC were 1.1%, 3.4%, and 10.5%, respectively (P = .29). Except for the thyroid gland, SPC and NDC were located outside the head and neck region. Univariate analysis was unable to identify any variable significantly predictive of SPC or NDC.

Conclusions and Relevance  In the present study, there was no statistical difference in the SPC cumulative incidence between the SGC and control groups, which might result from the possible limitation of a small sample size.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure.
Kaplan-Meier Curves

Kaplan-Meier curves showing the cumulative incidence of second primary cancers (SPCs) in patients with salivary gland carcinoma and of newly developed cancers in control individuals without cancer history (log-rank test, P = .29).

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
Jobs
JAMAevidence.com

The Rational Clinical Examination
Make the Diagnosis: Cancer, Family History

The Rational Clinical Examination
Original Article: Does This Patient Have a Family History of Cancer?

brightcove.createExperiences();