Submitted for Publication: February 26, 2014; final revision received August 6, 2014; accepted September 1, 2014.
Published Online: October 30, 2014. doi:10.1001/jamaoto.2014.2669.
Study concept and design: Krings, Wineland, Rodebaugh, Piccirillo.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Krings, Kallogjeri, Nicklaus, Piccirillo.
Critical revision of the manuscript for important intellectual content: Krings, Wineland, Rodebaugh, Nicklaus, Lenze, Piccirillo.
Statistical analysis: Krings, Kallogjeri, Rodebaugh, Piccirillo.
Obtained funding: Krings, Piccirillo.
Administrative, technical, or material support: Krings, Kallogjeri, Nicklaus.
Study supervision: Krings, Wineland, Nicklaus, Piccirillo.
Conflict of Interest Disclosures: Dr Lenze receives support from Roche and Lundbeck to conduct research unrelated to that described in this article. No other disclosures are reported.
Funding/Support: This research was supported by a grant from the Doris Duke Clinical Research Foundation, as well as support from the Stanford University Medical Scholars Fellowship. Posit Science provided access to the Brain Fitness Program for all participants.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.