Submitted for Publication: April 1, 2014; final revision received June 3, 2014; accepted July 4, 2014.
Published Online: December 18, 2014. doi:10.1001/jamaoto.2014.3208.
Study concept and design: Antonelli, Ojano-Dirain.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Esin, Ojano-Dirain.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Ojano-Dirain.
Administrative, technical, or material support: All authors.
Study supervision: Esin, Ojano-Dirain.
Conflict of Interest Disclosures: Dr Antonelli has previously received financial support from Medtronic ENT (grant support and consulting fees) and Alcon Laboratories (grant support and honoraria for speaking engagements and advisory board service). No other disclosures are reported.
Funding/Support: Financial support for this study was provided by the University of Florida. Tympanostomy tubes were provided by Medtronic ENT.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentation: This study was presented at the Triological Society Combined Sections Meeting; January 11, 2014; Miami, Florida.
Additional Contributions:H influenzae strain 62094 and S aureus strain 29213 were donated by David Stroman, PhD, Alcon Research, Ltd.