Submitted for Publication: December 2, 2014; final revision received January 26, 2015; accepted February 20, 2015.
Published Online: April 9, 2015. doi:10.1001/jamaoto.2015.0471.
Study concept and design: Wirtz, Tyson, Weaver.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Wirtz, Hoshino, Weaver.
Critical revision of the manuscript for important intellectual content: Wirtz, Maldonado, Tyson, Weaver.
Statistical analysis: Wirtz, Maldonado, Tyson, Weaver.
Administrative, technical, or material support: Wirtz, Hoshino, Weaver.
Funding/Support: Funding was provided by National Institutes of Health–National Cancer Institute grant R01-CA163592 to A.M.W. and Pilot funding from the Robert J. Kleberg Jr and Helen C. Kleberg Foundation via the Vanderbilt-Ingram Cancer Center to E.D.W. and A.M.W.
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government.
Previous Presentation: These data were presented at the American Academy of Otolaryngology Annual Meeting; September 22, 2014; Orlando, Florida.
Additional Contributions: We thank Vito Quaranta, MD, and members of his laboratory for use of and help with the CellaVista microscope, Jim Netterville, MD, and members of the Weaver laboratory for advice and assistance with this project. We thank Gerard Milano, PhD, for providing the CAL-33 cell line and Harvey Babich, PhD, for providing the HSC-2 cell line.