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Case Report/Case Series |

Intraocular Pressure Changes in Emergent Surgical Decompression of Orbital Compartment Syndrome FREE

Fatemeh Mohammadi, MD1; Ali Rashan, MD1; Alkis Psaltis, MD, PhD, FRACS1,3; Agnieszka Janisewicz, MD1; Peter Li, MD1; Tarek El-Sawy, MD, PhD2; Jayakar V. Nayak, MD, PhD1
[+] Author Affiliations
1Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine, Stanford, California
2Department of Ophthalmology–Oculoplastics Service, Stanford University School of Medicine, Stanford, California
3Department of Otolaryngology–Head and Neck Surgery, University of Adelaide, Adelaide, South Australia, Australia
JAMA Otolaryngol Head Neck Surg. 2015;141(6):562-565. doi:10.1001/jamaoto.2015.0524.
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Published online

ABSTRACT

Importance  Orbital compartment syndrome is an acute rise in intraorbital volume resulting in increased intraorbital pressure and possible ischemic compromise of the optic nerve. Tonometric pressure measurement of intraocular pressure can aid surgeons in the diagnosis of this condition and in choosing the need to proceed with emergent surgical intervention. In addition, we present an unexpected cause of orbital compartment syndrome following routine frontal sinus irrigation.

Observations  An emergent lateral canthotomy and cantholysis followed by endoscopic medial wall decompression were performed, with intraocular pressure measurements performed throughout the evolution of this successful, and vision sparing, set of procedures. The techniques and continuous improvements in intraocular pressure measurements are described.

Conclusions and Relevance  There are only rare reports of the progression of intraocular pressure prior to, and concurrent with, surgical orbital decompression. While no absolute threshold for intraocular pressure exists for when surgical decompression should be performed, the decision of when and which decompression procedures to undertake should be based on clinical judgment and experience. Availability of tonometry in the operating room serves to measure response to management in these rare but challenging settings where intervention may be required to prevent irreversible visual loss.

Figures in this Article

INTRODUCTION

Orbital compartment syndrome (OCS) is an ophthalmologic surgical emergency resulting from an acute rise in intraorbital volume and pressure. A number of conditions can cause OCS, including retrobulbar hemorrhage, orbital emphysema, orbital cellulitis, orbital edema, and foreign body entry into the orbital socket. A marked increase in the intraocular pressure (IOP) and subsequent compression of the optic nerve and associated vasculature can lead to rapid functional compromise and blindness. To prevent visual loss, rapid diagnosis and urgent performance of surgical decompression via lateral canthotomy and cantholysis, and/or endoscopic medial orbital decompression, are often required, although ultimately “pulling the trigger” on orbital decompression can be a challenging decision to undertake for most clinicians. Tonometric pressure measurements of IOP can be a helpful indicator in choosing to proceed with surgical intervention,1,2 although the objective benefit of each of these independent interventions has never previously been reported intraoperatively. Here, we tabulate our use of continuous IOP measurements recorded during emergent surgical decompression of OCS, which reveals the progressive decrement in IOP achieved through each individual interventional procedure.

REPORT OF A CASE

During endoscopic sinus surgery under general anesthesia, a middle-aged woman with chronic rhinosinusitis and focal areas of bone erosion in the paranasal sinuses (Figure, A, B) underwent routine irrigation of the left frontal recess and sinus outflow tract using a curved suction attached to a 20 cm3 saline syringe to clear purulent discharge from the endoscopic field. The patient demonstrated an immediate, unexpected left orbital swelling, which initially subsided over 7 to 8 minutes, with both eyes soft, and pupils equal, round, and reactive to light on examination. As the case resumed, approximately 4 minutes later, the left eye exhibited a second sequence of rapid, progressive, and now unremitting, edema, with the development of left-eye proptosis with chemosis. The rhinology and ophthalmology services were then immediately paged to the operating theater, while the primary surgery team obtained a tonometer for IOP readings (Table).

Place holder to copy figure label and caption
Figure.
Preoperative and Postdecompression Imaging of Sinuses and Orbit

A, Preoperative sinus computed tomographic (CT) scan reveals extensive left-sided pansinus mucosal thickening and supraorbital rim dehiscence from bone erosion (arrowhead). B, Preoperative magnetic resonance image of the left frontal sinus suggests absence of preexisting frontal sinus mucosal defects or depressions into the orbital vault at the site of bony dehiscence (arrowhead). C, Postoperative day 0 sinus CT status after external and endoscopic decompressions indicates cause of orbital compartment syndrome to be sizeable extraorbital fluid collection (asterisk) present within orbital vault despite now-normalized intraocular pressures. Postsurgical changes following medial orbital wall decompression with herniation of intraorbital fat through endoscopic surgical decompression site, are demonstrated (arrowhead).

Graphic Jump Location
Table Graphic Jump LocationTable.  Continuous IOP Measurements During, and Following, Surgical Decompression

Twenty minutes after initial frontal irrigation and tonometer retrieval, an IOP of 50 mm Hg was measured in the affected eye, compared with 18 mm Hg in the contralateral (right) eye, confirming left-eye OCS, but no interventions were performed owing to surgeon hesitation to embark on this procedure. Following arrival of the consulting services in the subsequent 8 to 10 minutes, the IOP increased to 58 mm Hg, and an emergent lateral canthotomy and cantholysis with inferior canthal tendon release was performed. These sequential, coordinated external procedures reduced the IOP nearly 40%, from 58 to 35 mm Hg. With the endoscopic sinus equipment already open and available in the surgical theater, and given the persistently elevated IOP of 35 mm Hg after external decompression, endoscopic medial orbital wall decompression was then performed.

Following efficient left total ethmoidectomy and sphenoidotomy to obtain landmarks in this infected, inflamed, and hemorrhagic surgical field, the left lamina papyracea was identified and rapidly taken down. The exposed periorbital sheath was then incised from the optic strut posteriorly to the level of the maxillary sinus natural ostium anteriorly to allow prolapse of orbital fat into the intrasinus space and additional decompression of the orbital vault (Figure, C). This procedure decreased tonometric pressure an additional 10 points to 25 mm Hg (supplemental 17% reduction in IOP from peak level), after which the case was concluded and the patient extubated. In the postanesthesia care unit, the patient was found to have no relative afferent pupillary defect (RAPD) with the ability to count fingers, with stable IOPs of 25 mm Hg in the affected eye.

Postoperatively, intravenous antibiotics, dexamethasone, and carbonic anhydrase inhibitors were administered. On postoperative day 1, the patient’s visual acuity was normal and symmetric in both eyes at 20/100 without correction, and, as noted in the Table, IOPs were 15 mm Hg in the affected left eye and 10 mm Hg in the right. Postoperative review of the preoperative computed tomographic (CT) and magnetic resonance imaging (MRI) scans revealed left supraorbital rim dehiscence and erosion with no mucosal defects or depressions from the left frontal sinus into the orbit. Postexigency, the patient experienced some delayed but progressive sharp left retro-orbital pain with upward gaze with normal IOP. This was felt to be due to the remnant supraorbital fluid collection, which was uneventfully drained by the ophthalmology service on postoperative day 4. The patient made an excellent recovery after this and was discharged on postoperative day 6 after bedside cosmetic repair of the left cantholysis site.

DISCUSSION

Acute OCS is a complication of rapid increased pressure within the orbital space.3,4 Typically, an IOP greater than 20 mm Hg is considered elevated,5 and an increased IOP may compress the optic nerve directly or cause compression of its vasculature.3,4 An enlarged blind spot on visual field testing, decreased color vision most notably red desaturation, and a RAPD are considered the most reliable clinical indicators of optic nerve compromise.3,6 Central retinal artery occlusion (CRAO) can be another mechanism of acute visual loss,3,4 but proptosis and chemosis do not typically manifest in concert with isolated CRAO.

To protect against visual loss in the setting of a retrobulbar hemorrhage, it has been recommended that decompression of the affected orbit should be performed within 100 to 120 minutes of symptom onset.1,4 Hayreh and Weingeist7 performed 2 experimental studies on central retinal artery occlusion. In their study7 on aged monkeys, the retina was found to tolerate acute ischemia for up to 98 minutes with full recovery, but after 105 minutes the damage was considered irreversible. In contrast, in younger monkeys, there was a variable degree of damage in CRAO of 105 to 240 minutes. Total optic nerve atrophy occurred after 240 minutes.8 While not directly overlapping with OCS, these findings in CRAO are clearly relevant to understanding the sensitivity of timing to preserve optic nerve function.

Rapid diagnosis and treatment is necessary to avoid permanent blindness in OCS.24,9 Treatments are usually chosen based on degree of vision loss, pupillary examination, and tonometric pressure. Evidence suggests that proptosis is not a reliable prognostic factor of vision loss.2,10 In contrast, tonometric pressure may be the best predictive factor. Experimental studies of cadavers confirm the accuracy of IOP measurements with a tonometer in management of OCS.11 However, a consensus IOP on which to embark on surgical decompression remains controversial. Han et al2 compared the change in orbital pressure of the affected orbit with the normal contralateral orbit. They recommend orbital decompression in the presence of a tonometric pressure less than 20 mm Hg below the mean arterial pressure, a marked RAPD, or no retinal artery pulsation on ophthalmologic examination. Alternatively, others have suggested that an IOP greater than 40 mm Hg, as well as signs of optic nerve compression or CRAO, as indications for lateral canthotomy and cantholysis.5,12 Still other groups suggest an IOP greater 30 mm Hg as an indication for surgical intervention.13

Imaging studies, such as CT and/or MRI scans, can be helpful to make an accurate diagnosis, but it is universally agreed that surgical decompression of the orbit should not be delayed on the basis of obtaining imaging.3,9 However, because of its availability and celerity, CT scan is the preferred imaging technique to identify the location and source of elevated orbital pressure.3 Interestingly, Oester et al10 compared the stretch angle between the patient’s eyes using axial CT images to predict poor visual outcome in patients with OCS.

Immediate lateral canthotomy and inferior cantholysis are recommended to prevent visual loss owing to optic nerve compression in OCS.2,5,10 The major goal of these external procedures is to allow anterior prolapse of the orbital contents to rapidly reduce the IOP and reestablish retinal arterial blood flow. The full-thickness incision should be made from the lateral canthus extending toward the orbital rim. Inferior (and occasionally superior) cantholysis is performed by releasing the crus of the lateral canthal tendon, resulting in complete lower eyelid laxity and mobility.5 It should be noted that the orbital contents and eyelid soft tissues are highly edematous and under tension in these emergent scenarios, such that reliable hand instrumentation (eg, heavy tonotomy scissors, DeBakey forceps), and, moreover, mental commitment as to the necessity of the procedure, are mandatory for achieving successful decompression.

Endoscopic orbital decompression is another surgical approach that can be used in the treatment of compressive optic neuropathy.14 In such cases, it is important to decompress the anterior and posterior aspects of the medial and inferior walls of the orbit. Studies have shown variable but significant reduction in IOP after decompression surgery. Onaran et al15 have, for example, reported increased IOP in Graves orbitopathy leading to compression of the vein and reduced venous outflow. In this study,15 a clinically significant reduction in IOP as well as a decrease in venous pressure were both observed following orbital decompression.

The ultimate, rare, and possibly unreported cause of OCS in this patient also deserves added attention. In hindsight, routine frontal sinus irrigation of saline through a narrow frontal recess or ostium in this patient, without adequate egress, produced entrapment and accumulation of fluid within the left frontal sinus and a breach along the “path of least resistance” through the tenuous mucosa overlying the supraorbital rim bony defect. This ultimately resulted in periorbital accumulation of fluid within the orbi, leading to a most unusual manifestation of OCS. The primary surgeon had noted the rim defect preoperatively on CT imaging, and an MRI scan prior to surgery confirmed an intact frontal sinus mucosal floor. Because the left frontal recess was challenging to dissect in this setting of florid sinus infection, saline irrigation was intentionally used to clear the endoscopic surgical field. Unfortunately, in this particular patient, the frontal outflow channel was too narrow to allow immediate outflow of saline irrigant from the frontal outflow tract once introduced at moderate pressure through a syringe from below.

Finally, past studies have reported tonometric measurements in cases of OCS preoperatively and postoperatively,2 but the objective benefit conferred by continuous, sequential measurements of IOP through the evolution of successful surgical decompression has, to our knowledge, not previously been reported. In this specific case, an approximate 60% overall reduction in IOPs was obtained within 30 minutes from the initiation of surgical decompression. Continuous tonometer measurements were conducted up to postoperative day 1, comparing the pressures of the affected eye with the contralateral eye as internal control. A supraorbital rim transconjunctival decompression to drain the extraorbital fluid intraoperatively may have also been entertained given the likely location of the extravasated fluid based on the defect (Figure, C). However, with the emergent scenario faced in this intraoperative emergency, after successful external decompression achieved through canthotomy and cantholysis, medial orbital decompression was next undertaken given (1) high levels of experience with this procedure for those physicians present, (2) the immediate availability of this equipment in the operating room, (3) the limited morbidity and high level of benefit of this adjunct procedure, and (4) lack of more precise information on the fluid collection size and depth at the time. A second external decompression approach may have been considered if the procedures described herein were unsuccessful in reducing the IOP, although without additional imaging, the effectiveness of this approach may have been suboptimal.

CONCLUSIONS

Because some patients have more tenuous ocular vascular supply, it should be emphasized that there is no absolute threshold for IOP when surgical decompression should be performed—this remains a clinical judgment based on factors and circumstances that vary with each scenario. Similarly, the need to perform both external and endoscopic decompression is not well established, and although it was beneficial in this case, the decision of which decompression procedures to undertake should also be based on clinical judgment and experience. Finally, availability of tonometry in the operating room may assist the otolaryngology and ophthalmology surgical teams to predict and monitor cases in which OCS in a concern. It also serves to measure response to management in these rare but challenging settings where intervention may be required to prevent irreversible visual loss.

ARTICLE INFORMATION

Corresponding Author: Jayakar V. Nayak, MD, PhD, Department of Otolaryngology–Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Stanford, CA 94305 (jnayak@ohns.stanford.edu).

Submitted for Publication: August 4, 2014; final revision received October 9, 2014; accepted November 4, 2014.

Published Online: April 16, 2015. doi:10.1001/jamaoto.2015.0524.

Author Contributions: Dr Nayak had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Mohammadi, Rashan, Psaltis, Li, El-Sawy, Nayak.

Acquisition, analysis, or interpretation of data: Mohammadi, Rashan, Janisewicz, Li, Nayak.

Drafting of the manuscript: Mohammadi, Rashan, Nayak.

Critical revision of the manuscript for important intellectual content: All authors.

Administrative, technical, or material support: Psaltis, Janisewicz, Li, Nayak.

Study supervision: Rashan, Psaltis, Li, El-Sawy, Nayak.

Conflict of Interest Disclosures: None reported.

REFERENCES

Ballard  SR, Enzenauer  RW, O’Donnell  T, Fleming  JC, Risk  G, Waite  AN.  Emergency lateral canthotomy and cantholysis: a simple procedure to preserve vision from sight threatening orbital hemorrhage. J Spec Oper Med. 2009;9(3):26-32.
PubMed
Han  JK, Caughey  RJ, Gross  CW, Newman  S.  Management of retrobulbar hematoma. Am J Rhinol. 2008;22(5):522-524. doi:10.2500/ajr.2008.22.3217.
PubMed   |  Link to Article
Lima  V, Burt  B, Leibovitch  I, Prabhakaran  V, Goldberg  RA, Selva  D.  Orbital compartment syndrome: the ophthalmic surgical emergency. Surv Ophthalmol. 2009;54(4):441-449. doi:10.1016/j.survophthal.2009.04.005.
PubMed   |  Link to Article
Winterton  JV, Patel  K, Mizen  KD.  Review of management options for a retrobulbar hemorrhage. J Oral Maxillofac Surg. 2007;65(2):296-299. doi:10.1016/j.joms.2005.11.089.
PubMed   |  Link to Article
Knoop  KJ, Dennis  WR. Ophthalmologic procedures. In: Robert  JR, ed. Clinical Procedures in Emergency Medicine.6th ed. Philadelphia, PA: Elsevier; 2014:1259-1297.
Behbehani  R.  Clinical approach to optic neuropathies. Clin Ophthalmol. 2007;1(3):233-246.
PubMed
Hayreh  SS, Weingeist  TA.  Experimental occlusion of the central artery of the retina, IV: retinal tolerance time to acute ischaemia. Br J Ophthalmol. 1980;64(11):818-825.
PubMed   |  Link to Article
Hayreh  SS, Zimmerman  MB, Kimura  A, Sanon  A.  Central retinal artery occlusion: retinal survival time. Exp Eye Res. 2004;78(3):723-736.
PubMed   |  Link to Article
Brucoli  M, Arcuri  F, Giarda  M, Benech  R, Benech  A.  Surgical management of posttraumatic intraorbital hematoma. J Craniofac Surg. 2012;23(1):e58-e61. doi:10.1097/SCS.0b013e3182418cc9.
PubMed   |  Link to Article
Oester  AE  Jr, Sahu  P, Fowler  B, Fleming  JC.  Radiographic predictors of visual outcome in orbital compartment syndrome. Ophthal Plast Reconstr Surg. 2012;28(1):7-10. doi:10.1097/IOP.0b013e31822672c4.
PubMed   |  Link to Article
Oester  AE  Jr, Fowler  BT, Fleming  JC.  Inferior orbital septum release compared with lateral canthotomy and cantholysis in the management of orbital compartment syndrome. Ophthal Plast Reconstr Surg. 2012;28(1):40-43. doi:10.1097/IOP.0b013e31823646f3.
PubMed   |  Link to Article
Harrahill  M.  A case report of traumatic eye compartment syndrome. J Emerg Nurs. 2006;32(1):104-105. doi:10.1016/j.jen.2005.09.005.
PubMed   |  Link to Article
Cubano  MA. Emergency War Surgery. 4th ed. Falls Church, VA: US Department of Defense, US Army, Office of the Surgeon General; 2013:205-217.
Kingdom  TT, Durairaj  VD. Endoscopic applications in orbital surgery. In: Kennedy  DW, Hwang  PH, eds. Rhinology: Diseases of the Nose, Sinuses, and Skull Base. New York, NY: Thieme; 2012:425-443.
Onaran  Z, Konuk  O, Oktar  SO, Yücel  C, Unal  M.  Intraocular pressure lowering effect of orbital decompression is related to increased venous outflow in Graves orbitopathy. Curr Eye Res. 2014;39(7):666-672.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure.
Preoperative and Postdecompression Imaging of Sinuses and Orbit

A, Preoperative sinus computed tomographic (CT) scan reveals extensive left-sided pansinus mucosal thickening and supraorbital rim dehiscence from bone erosion (arrowhead). B, Preoperative magnetic resonance image of the left frontal sinus suggests absence of preexisting frontal sinus mucosal defects or depressions into the orbital vault at the site of bony dehiscence (arrowhead). C, Postoperative day 0 sinus CT status after external and endoscopic decompressions indicates cause of orbital compartment syndrome to be sizeable extraorbital fluid collection (asterisk) present within orbital vault despite now-normalized intraocular pressures. Postsurgical changes following medial orbital wall decompression with herniation of intraorbital fat through endoscopic surgical decompression site, are demonstrated (arrowhead).

Graphic Jump Location

Tables

Table Graphic Jump LocationTable.  Continuous IOP Measurements During, and Following, Surgical Decompression

References

Ballard  SR, Enzenauer  RW, O’Donnell  T, Fleming  JC, Risk  G, Waite  AN.  Emergency lateral canthotomy and cantholysis: a simple procedure to preserve vision from sight threatening orbital hemorrhage. J Spec Oper Med. 2009;9(3):26-32.
PubMed
Han  JK, Caughey  RJ, Gross  CW, Newman  S.  Management of retrobulbar hematoma. Am J Rhinol. 2008;22(5):522-524. doi:10.2500/ajr.2008.22.3217.
PubMed   |  Link to Article
Lima  V, Burt  B, Leibovitch  I, Prabhakaran  V, Goldberg  RA, Selva  D.  Orbital compartment syndrome: the ophthalmic surgical emergency. Surv Ophthalmol. 2009;54(4):441-449. doi:10.1016/j.survophthal.2009.04.005.
PubMed   |  Link to Article
Winterton  JV, Patel  K, Mizen  KD.  Review of management options for a retrobulbar hemorrhage. J Oral Maxillofac Surg. 2007;65(2):296-299. doi:10.1016/j.joms.2005.11.089.
PubMed   |  Link to Article
Knoop  KJ, Dennis  WR. Ophthalmologic procedures. In: Robert  JR, ed. Clinical Procedures in Emergency Medicine.6th ed. Philadelphia, PA: Elsevier; 2014:1259-1297.
Behbehani  R.  Clinical approach to optic neuropathies. Clin Ophthalmol. 2007;1(3):233-246.
PubMed
Hayreh  SS, Weingeist  TA.  Experimental occlusion of the central artery of the retina, IV: retinal tolerance time to acute ischaemia. Br J Ophthalmol. 1980;64(11):818-825.
PubMed   |  Link to Article
Hayreh  SS, Zimmerman  MB, Kimura  A, Sanon  A.  Central retinal artery occlusion: retinal survival time. Exp Eye Res. 2004;78(3):723-736.
PubMed   |  Link to Article
Brucoli  M, Arcuri  F, Giarda  M, Benech  R, Benech  A.  Surgical management of posttraumatic intraorbital hematoma. J Craniofac Surg. 2012;23(1):e58-e61. doi:10.1097/SCS.0b013e3182418cc9.
PubMed   |  Link to Article
Oester  AE  Jr, Sahu  P, Fowler  B, Fleming  JC.  Radiographic predictors of visual outcome in orbital compartment syndrome. Ophthal Plast Reconstr Surg. 2012;28(1):7-10. doi:10.1097/IOP.0b013e31822672c4.
PubMed   |  Link to Article
Oester  AE  Jr, Fowler  BT, Fleming  JC.  Inferior orbital septum release compared with lateral canthotomy and cantholysis in the management of orbital compartment syndrome. Ophthal Plast Reconstr Surg. 2012;28(1):40-43. doi:10.1097/IOP.0b013e31823646f3.
PubMed   |  Link to Article
Harrahill  M.  A case report of traumatic eye compartment syndrome. J Emerg Nurs. 2006;32(1):104-105. doi:10.1016/j.jen.2005.09.005.
PubMed   |  Link to Article
Cubano  MA. Emergency War Surgery. 4th ed. Falls Church, VA: US Department of Defense, US Army, Office of the Surgeon General; 2013:205-217.
Kingdom  TT, Durairaj  VD. Endoscopic applications in orbital surgery. In: Kennedy  DW, Hwang  PH, eds. Rhinology: Diseases of the Nose, Sinuses, and Skull Base. New York, NY: Thieme; 2012:425-443.
Onaran  Z, Konuk  O, Oktar  SO, Yücel  C, Unal  M.  Intraocular pressure lowering effect of orbital decompression is related to increased venous outflow in Graves orbitopathy. Curr Eye Res. 2014;39(7):666-672.
PubMed   |  Link to Article

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