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Clinical Challenge | Pathology

Postradiation Tumor in the Floor of Mouth QUIZ

Yun-Ting Chao, MD1; Wing-Yin Li, MD2,3; Pen-Yuan Chu, MD1,4
[+] Author Affiliations
1Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
2Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
3Department of Pathology, National Yang-Ming University, School of Medicine, Taipei, Taiwan
4Department of Otorhinolaryngology, National Yang-Ming University, School of Medicine, Taipei, Taiwan
JAMA Otolaryngol Head Neck Surg. 2015;141(7):663-664. doi:10.1001/jamaoto.2015.0882.
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A woman in her 50s presented with foreign body sensation in her throat, mild odynophagia, and dyspnea. She had a history of adenoid cystic carcinoma of the right submandibular gland and had undergone wide tumor excision and postoperative radiation therapy. What is the diagnosis?

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A, Axial T1-weighed gadolinium-enhanced magnetic resonance image of the neck. B, Gross image of the surgical specimen. C, Histopathologic image. Hematoxylin-eosin, original magnification ×200. D, Histopathologic image. S-100 protein stain, original magnification ×200.

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