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Facial Paresis Secondary to an Aggressive Acute Bacterial Rhinosinusitis FREE

Arya W. Namin, BA1; Mary S. Czerny, MD2; Jastin L. Antisdel, MD2
[+] Author Affiliations
1St Louis University School of Medicine, St Louis, Missouri
2Department of Otolaryngology–Head and Neck Surgery, St Louis University School of Medicine, St Louis, Missouri
JAMA Otolaryngol Head Neck Surg. 2015;141(9):856-857. doi:10.1001/jamaoto.2015.1086.
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Published online

When approaching a patient with cranial nerve 7 (CN7) palsy, a careful workup must be undertaken in order to rule out the many treatable etiologies, including the malignant and infectious. To guide the need for imaging, a careful medical history must elicit if the CN7 weakness had an abrupt onset or a progressive course. Bell palsy is diagnosed only if potential etiologies of the CN7 lesion have been confidently ruled out.

REPORT OF A CASE

A man in his 50s presented to a tertiary care emergency department (ED) with a 5-week history of right facial paresis, facial numbness, and severe ipsilateral headaches. He had presented to an outside ED shortly after the onset of his facial weakness and headaches 5 weeks prior and was diagnosed as having Bell palsy. A computed tomographic (CT) scan was not obtained; he was treated with an unknown antibiotic and did not receive steroids.

The patient had a medical history of poorly controlled diabetes mellitus and hypothyroidism. Physical examination revealed right-sided chemosis and exophthalmos, purulent nasal secretions, and maxillary nerve hypoesthesia. Neurological examination revealed complete eye closure with effort, moderate brow weakness, and lip droop with effort, for an overall House-Brackmann III right facial paresis. The left facial nerve was intact. Nasal endoscopy showed polypoid changes of right middle turbinate and purulence within the nasal cavity. No necrotic debris was seen. The patient had a white blood cell count that was at the high end of normal.

A CT scan of the head showed right-sided rhinosinusitis with erosion of the superior (Figure 1) and posterolateral wall of the maxillary sinus (Figure 2). There was evidence of an orbital abscess, as well as purulence extending into the infratemporal fossa with tracking into the parotid, caudal to the stylomastoid foramen (Figure 2). There was no radiographic evidence of neo-osteogenesis (Figure 1) or clinical history of chronic rhinosinusitis.

Place holder to copy figure label and caption
Figure 1.
Coronal Computed Tomographic Scan on Day of Presentation

The orbital abscess is an extension of the right-sided rhinosinusitis through the superior wall of the maxillary sinus (yellow arrowhead). Erosion into the zygomatic bone (white arrowhead) was also noted. There was no evidence of neo-osteogenesis in either the right or left maxillary sinuses.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Axial Computed Tomographic Scan on Day of Presentation

A, The lamina papyracea appeared to be intact. B, Disease tracked to the condylar process (arrowhead). Disease could not be identified at the stylomastoid foramen. C, Disease tracked caudally to the condylar neck (arrowhead). D, Disease extended caudally and posteriorly around the mandibular ramus into the parotid (arrowheads). Disease also nearly abutted the styloid process.

Graphic Jump Location

The patient was initially treated with intravenous antimicrobials, antimicrobial eye drops, steroid nasal spray, and saline sinus irrigations. On the day of admission, he underwent right endoscopic sinus surgery with concomitant endoscopic drainage of the orbital abscess. Transantral drainage of the infratemporal fossa abscess was also performed through the eroded posterior maxillary sinus wall. Pathologic findings were notable for chronic inflammation and fibropurulent exudate without evidence of fungus. Cultures grew coagulase-negative Staphylococcus aureus and Enterococcus faecalis.

On hospital day 8, the patient began to have sensation return to the right cheek. He was discharged home on hospital day 10 with 6 weeks of oral antibiotics, saline irrigations, and nasal steroid spray. Facial nerve function remained House-Brackmann III at his last examination 4 months after presentation. The patient was lost to follow-up.

DISCUSSION

No case of CN7 palsy secondary to bacterial sinusitis was found in the medical literature. In the current case presentation, the patient’s acute rhinosinusitis was diagnosed as Bell palsy 5 weeks prior to presentation.

After 5 weeks of disease persistence, CT findings of purulence tracking into the parotid near the stylomastoid foramen suggest this location as the site of injury to the facial nerve. The V2 hypoesthesia this patient experienced is likely due to inflammatory damage to V2. The involvement of 2 cranial nerves secondary to this patient’s acute rhinosinusitis highlights an unusual link between bacterial sinonasal disease and skull base pathology.

Given the patient’s history of poorly controlled diabetes mellitus, rhino-orbital-cerebral mucormycosis was suspected in this case.1 Given the lack of pathological evidence of fungal infection and improvement without antifungal agents in this case presentation, a fungal etiology was highly unlikely. While a strong association between sinusitis and facial paresis has not been found, Caroli et al2 presented a case of sinus aspergillosis associated with cranial nerve seven palsy. Other bacterial infections, such as otitis externa, mastoiditis, osteitis mastoidea and eustachitis, can lead to CN7 palsy, albeit at a location proximal to the stylomastoid foramen.3

CONCLUSIONS

We present the first reported case, to our knowledge, of CN7 paresis secondary to acute bacterial sinusitis. The initial diagnosis as Bell palsy underscores the importance of considering a broad differential diagnosis, particularly in an immunocompromised patient such as one with poorly controlled diabetes mellitus.

ARTICLE INFORMATION

Corresponding Author: Jastin L. Antisdel, MD, St Louis University School of Medicine, 3635 Vista Ave, 6FDT, St Louis, MO 63110 (antisdel@slu.edu).

Published Online: June 18, 2015. doi:10.1001/jamaoto.2015.1086.

Conflict of Interest Disclosures: None reported.

Previous Presentation: This case was presented at the American Rhinologic Society at Combined Otolaryngology Spring Meetings; May 16, 2014; Las Vegas, Nevada.

REFERENCES

Bhansali  A, Bhadada  S, Sharma  A,  et al.  Presentation and outcome of rhino-orbital-cerebral mucormycosis in patients with diabetes. Postgrad Med J. 2004;80(949):670-674. doi:10.1136/pgmj.2003.016030.
PubMed   |  Link to Article
Caroli  A, Joosen  E, Van Huyneghem  L, Dourov  N, Heyman  R.  A case of sinus aspergillosis associated with peripheral facial paralysis [in French]. Acta Stomatol Belg. 1985;82(3):167-174.
PubMed
Liu  J, Li  Y, Yuan  X, Lin  Z.  Bell’s palsy may have relations to bacterial infection. Med Hypotheses. 2009;72(2):169-170.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.
Coronal Computed Tomographic Scan on Day of Presentation

The orbital abscess is an extension of the right-sided rhinosinusitis through the superior wall of the maxillary sinus (yellow arrowhead). Erosion into the zygomatic bone (white arrowhead) was also noted. There was no evidence of neo-osteogenesis in either the right or left maxillary sinuses.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Axial Computed Tomographic Scan on Day of Presentation

A, The lamina papyracea appeared to be intact. B, Disease tracked to the condylar process (arrowhead). Disease could not be identified at the stylomastoid foramen. C, Disease tracked caudally to the condylar neck (arrowhead). D, Disease extended caudally and posteriorly around the mandibular ramus into the parotid (arrowheads). Disease also nearly abutted the styloid process.

Graphic Jump Location

Tables

References

Bhansali  A, Bhadada  S, Sharma  A,  et al.  Presentation and outcome of rhino-orbital-cerebral mucormycosis in patients with diabetes. Postgrad Med J. 2004;80(949):670-674. doi:10.1136/pgmj.2003.016030.
PubMed   |  Link to Article
Caroli  A, Joosen  E, Van Huyneghem  L, Dourov  N, Heyman  R.  A case of sinus aspergillosis associated with peripheral facial paralysis [in French]. Acta Stomatol Belg. 1985;82(3):167-174.
PubMed
Liu  J, Li  Y, Yuan  X, Lin  Z.  Bell’s palsy may have relations to bacterial infection. Med Hypotheses. 2009;72(2):169-170.
PubMed   |  Link to Article

Correspondence

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