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Comment & Response |

Bringing Light to Dental Trauma and Oral Cavity Cancer—Reply

Brendan J. Perry, BSc, MBBS1; Andrew P. Zammit, BPharm, MBBS1; Christopher F. L. Perry, MBBS, DTM&H, FRACS2
[+] Author Affiliations
1Princess Alexandra Hospital, Brisbane, Queensland, Australia
2Watkins Medical Centre, 225 Wickham Terrace, Brisbane, Queensland, Australia
JAMA Otolaryngol Head Neck Surg. 2015;141(11):1029-1030. doi:10.1001/jamaoto.2015.2410.
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In Reply The focus of much current research has been the role of human papilloma virus (HPV) in oropharyngeal cancer, especially as a separate risk factor, or even disease process, compared with smoking-related cancer of the oropharynx. Our data1 support previous research showing that oral cavity cancer is slightly more prevalent than oropharyngeal cancer, and that this disparity is largely due to increased numbers of nonsmokers, especially women, who develop oral cavity cancers. In our series, oral cavity cancers occurred in lifelong nonsmokers in 87 patients compared with only 48 patients with oropharyngeal cancer. Mentioning HPV in the title of our article1 was partly to bring attention to the fact that despite the significant research focus on HPV oropharyngeal cancers, nonsmokers are much more likely to develop oral cavity cancers, and a risk factor more important than HPV may be as yet be unrecognized or underinvestigated.

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November 1, 2015
Jennifer L. Frustino, DDS, PhD; Maureen A. Sullivan, DDS; Nestor R. Rigual, MD
1Division of Oral Oncology and Maxillofacial Prosthetics, Department of Dentistry, The Center for Oncology Care at Erie County Medical Center, Buffalo, New York
2Department of Head and Neck Surgery/Plastic and Reconstructive Surgery, The Center for Oncology Care at Erie County Medical Center, Buffalo, New York
JAMA Otolaryngol Head Neck Surg. 2015;141(11):1029. doi:10.1001/jamaoto.2015.2407.
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