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Clinical Note |

Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus

Benjamin S. Bleier, MD; Charles S. Gawthrop, MD; Erica R. Thaler, MD; Duane A. Sewell, MD; Kathleen T. Montone, MD; Douglas M. Marvel, BA; Alexander G. Chiu, MD
Arch Otolaryngol Head Neck Surg. 2008;134(7):778-780. doi:10.1001/archotol.134.7.778.
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Intranasal papillomas may be categorized by histologic origin as those arising from squamous or schneiderian epithelium. Squamous papillomas result from a proliferation of squamous epithelium into exophytic papillary fronds, are almost exclusively unilateral, and are usually pedicled in the nasal vestibule. Bilateral diffuse intranasal squamous papillomatosis represents a poorly described variant of this disease, which may represent a distinct pathologic process derived from an underlying human papillomavirus (HPV) infection, and its treatment should address this etiology. We report on 2 rare cases of diffuse intranasal papillomatosis and discuss their presentation, workup, HPV characterization, and treatment.

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Figure 1.

Endoscopic view of the left nasal cavity (S indicates septum; MT, middle turbinate; IT, inferior turbinate). Preoperative (A) and postoperative views (B). Thick arrow, nasal septal lesion; thin arrow, inferior turbinate lesion.

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Figure 2.

Sinonasal papilloma. A, Low-power view showing exophytic growth pattern (hematoxylin-eosin; original magnification × 10). B, Higher-power view showing focal squamous dysplasia (hematoxylin-eosin; original magnification × 40).

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