We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Clinical Note |

Sequelae of Rapid Growing Mycobacteria Otomastoiditis in a Child

Michael J. McAvoy, DO; Michael A. Carron, MD; Janet Poulik, MD; Dennis Altinok, MD; Walter Belenky, MD
Arch Otolaryngol Head Neck Surg. 2009;135(6):602-604. doi:10.1001/archoto.2009.52.
Text Size: A A A
Published online


and Mycobacterium peregrinum are nontuberculous mycobacteria (NTM). They belong to a subset of NTM known as rapid-growing mycobacteria (RGM), previously designated as Runyon class IV. Rapid-growing mycobacteria are saprophytic, ubiquitous in nature, and generally considered nonpathogenic. Several species of RGM, including M fortuitum and M peregrinum, are potentially pathogenic in humans. Mycobacterium fortuitum infections are typically cutaneous, occurring when the skin barrier has been breached. No pattern of infection by M peregrinum has been established. Herein, we discuss a pediatric case of otomastoiditis that progressed to petrous apicitis, intracranial empyema, and meningitis despite appropriate medical and surgical therapy. Initial laboratory identification in this case listed M fortuitum with a follow-up laboratory identification by the Centers for Disease Control and Prevention (CDC) listing the M fortuitum/M peregrinum group. Because the CDC did not classify to the species level we cannot be certain that this case was not caused by M peregrinum, which phylogenetically is very closely related to M fortuitum. It is a member of the M fortuitum group and was considered a biovariant of M fortuitum until 1992. There are no previous reports of M peregrinum causing an otologic infection in the literature. To our knowledge, only 2 cases of mastoiditis and 1 case of a subdural empyema in the pediatric population caused by M fortuitum are documented in the literature. Considering the aggressive nature and serious otologic and intracranial consequences of these rapid growing mycobacteria, it is important to document this in the literature.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

T2 weighted axial fast-spin echo fat-saturated image demonstrates diffuse increased signal of petrous and mastoid bone with associated partial erosion consistent with osteomyelitis.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Multiple granulomas with central necrosis, surrounded by epithelioid histiocytes, giant cells, and a collarette of lymphocytes (hematoxylin-eosin, original magnification × 4).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Gadolinium-enhanced T1 weighted axial fat-saturated image. The image demonstrates a small encapsulated collection within the cerebellopontine angle cistern on the right suggestive of epidural infected collection.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Gadolinium-enhanced T1 weighted coronal fat-saturated image. The image demonstrates extensive enhancement along the dural surface of the basal cistern on the right with associated small encapsulated collection consistent with basal meningitis and small subdural infected collection.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

4 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Collections
PubMed Articles