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Clinical Note |

Primary Leiomyosarcoma of the Sphenoid Sinus

Vijay R. Ramakrishnan, MD; Sherif Said, MD, PhD; Todd T. Kingdom, MD
Arch Otolaryngol Head Neck Surg. 2009;135(9):949-952. doi:10.1001/archoto.2009.114.
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Leiomyosarcoma (LMS) is a rare soft-tissue cancer of the head and neck, accounting for 1% to 2% of nasal cavity and paranasal sinus tumors. It is more commonly found in the gastrointestinal or genitourinary tract. Leiomyosarcoma of the head and neck is associated with a history of radiation therapy, retinoblastoma, chemotherapy, human immunodeficiency virus, or AIDS. We describe what we believe is the first case of an LMS of the sphenoid sinus in the English-language literature and include a review of the literature on LMS of the paranasal sinuses, which identified approximately 50 cases of primary sinonasal LMS.

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Figure 1.

Preoperative, noncontrast, axial, and reformatted coronal computed tomograms demonstrating an erosive mass in the right sphenoid sinus. A, Axial image. B, Coronal image.

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Figure 2.

Histologic appearance of the tumor showing the spindle cell and fascicular morphological features (hematoxylin-eosin, original magnification ×200).

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Figure 3.

High-power image of focal nuclear pleomorphism and mitotic activity (hematoxylin-eosin, original magnification ×400).

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