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Clinical Note |

Nasal Cavity Squamous Cell Carcinoma in Wegener's Granulomatosis

Jeannine Stein, MD; Sudhakar T. Sridharan, MD; Isaac Eliachar, MD; Alexander Niv, MD; Benjamin Wood, MD; Gary S. Hoffman, MD
Arch Otolaryngol Head Neck Surg. 2001;127(6):709-713. doi:10.1001/archotol.127.6.709.
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Wegener's granulomatosis is a chronic debilitating disease with multiple organ system involvement, variable course, and myriad complications that cause morbidity and mortality. We report 2 cases of nasal cavity squamous cell carcinoma occurring in long-standing Wegener's granulomatosis.

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Figure 1.

Nasal cavity squamous cell carcinoma (SCC), as well as postoperative and Wegener's granulomatosis anatomical changes. Extensive intranasal cartilaginous destruction and surgical alterations of the ethmoid sinuses and medial orbital walls. Soft tissue mass involving the superior nasal region, maxillary sinus, anterior maxillary table and skin, medial canthi, and right orbit. A separate left orbital intraconal mass illustrates presumed further development of preexisting pseudotumor. Definitive differentiation between progression of long-standing pseudotumor and SCC is not possible.

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Figure 2.

Invasive squamous cell carcinoma. Large pleomorphic hyperchromatic cells invading the submucosa.

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