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Clinical Note | December 2001

Eagle Syndrome Produced by a Granular Cell Tumor

Katrin Philipp, MD; E. Leon Barnes, MD; Ricardo L. Carrau, MD

Arch Otolaryngol Head Neck Surg. 2001;127(12):1499-1501. doi:10.1001/archotol.127.12.1499.

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Eagle syndrome includes elicitation of pain on swallowing, turning the head, or extending the tongue. The syndrome is thought to be caused by irritation of the glossopharyngeal nerve, most commonly caused by its impingement against an elongated styloid process. We present a rare case of a granular cell tumor presenting as Eagle syndrome. Granular cell tumors orignate from Schwann cells and are most common in the subcutaneous tissue of the head, neck, and oral cavity, especially the tongue. A granular cell tumor is typically benign and solitary, rarely malignant. The differential diagnosis, diagnostic algorithm, and treatment are presented.

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Granular cell tumor composed of cells with granular cytoplasm and round to spindle-shaped nuclei (hematoxylin-eosin, original magnification ×100). Inset shows periodic acid–Schiff–positive, diastase-resistant granules (original magnification ×100).

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Philipp K, Barnes E, Carrau RL. Eagle Syndrome Produced by a Granular Cell Tumor. Arch Otolaryngol Head Neck Surg. 2001;127(12):1499-1501. doi:10.1001/archotol.127.12.1499.

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Eagle Syndrome Produced by a Granular Cell Tumor

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