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Clinical Note |

A Case of Ectopic Parathyroid Gland Hyperplasia in the Pyriform Sinus

Akira Fukumoto, MD; Manabu Nonaka, MD; Tomonobu Kamio, MD; Eriko Kamura, MD; Chika Ozu, MD; Shunkichi Baba, MD; Yoshiharu Ohaki, MD
Arch Otolaryngol Head Neck Surg. 2002;128(1):71-74. doi:10.1001/archotol.128.1.71.
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Variability in the location of parathyroid glands is well recognized. There are usually 4 parathyroid glands located in the area of the thyroid gland, but embryologically, they may be found anywhere from the angle of the jaw to the pericardium. We report a case of an ectopic parathyroid gland in the pyriform sinus. It appeared as a tumorous lesion in the pyriform sinus owing to progress of secondary hyperparathyroidism.

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Figure 1.

Barium swallow image shows a regular round mass in the right pyriform sinus (arrow).

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Figure 2.

Direct rigid laryngoscopy shows a mass with pedicle from the postlateral wall of the right pyriform sinus.

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Figure 3.

Photomicrograph under hematoxylin-eosin stain of parathyroid gland hyperplasia in the pyriform sinus. A, Histologic specimen shows submucosal well-demarcated nodule composed of epithelial cell proliferation (original magnification ×10). B, High-power view shows admixture of clear cells and oxyphilic cells (original magnification ×50).

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Figure 4.

The immunohistochemical reaction for chromogranin is strongly positive (original magnification ×50).

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