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Poster Presentations: American Head and Neck Society |

P226 Lack of Exon 19 and 21 EGFR Mutations in Squamous Cell Head and Neck Cancer Specimens and Cell Lines

M. L. Carlson; B. R. Wuertz; J. Lin; G. L. Adams; R. S. Taylor; F. G. Ondrey
Arch Otolaryngol Head Neck Surg. 2006;132(8):910. doi:10.1001/archotol.132.8.910-a.
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Objective: It has recently been reported that epidermal growth factor receptor tyrosine kinase inhibition might be a more effective treatment strategy in patients harboring specific EGFR mutations. These mutations are prevalent in 3% to 7% of non–small-cell lung carcinomas. Our objective was to examine whether these mutations might be more common at other upper aerodigestive cancer sites.

Design: We extracted DNA from 20 head and neck squamous cell tumors and 4 squamous cell carcinoma cell lines and sequenced the receptors using previously published primer pairs. We then compared the results against reported mutations.

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