Clinical Note |

Interdigitating Dendritic Cell Sarcoma of Cervical Lymph Nodes

Stephen Jo, MD; Michael J. Babb, MD; Raymond L. Hilsinger Jr, MD
Arch Otolaryngol Head Neck Surg. 2006;132(11):1257-1259. doi:10.1001/archotol.132.11.1257.
Text Size: A A A
Published online


Interdigitating dendritic cell sarcoma (IDCS) is a malignant neoplasm that arises from the interdigitating reticular cells of the lymph node. Dendritic cells are a heterogeneous group of antigen-presenting cells that play a major role in innate and adaptive immune responses. Subtypes of dendritic cells include Langerhans cells, interdigitating dendritic cells, follicular dendritic cells, and dermal dendrocytes.1 Interdigitating dendritic cells reside in the T-cell areas of peripheral lymphoid tissue, including the paracortex of lymph node and tonsil, the splenic periarteriolar lymphoid sheaths, and the interfollicular areas of mucosa-associated lymphoid tissue, and are responsible for major histocompatibility complex–restricted stimulation of resting T cells. Interdigitating dendritic cell sarcoma is rare; to our knowledge, only 34 cases have been reported to date.14 Lymphadenopathy is the most common physical finding at presentation, and 42% of cases occur in the head and neck.1,2,4 Otolaryngologists evaluating a head and neck mass should therefore include IDCS in the differential diagnosis.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

Photomicrograph shows population of normal-appearing lymphocytes (right side) and large oval and polygonal tumor cells (left side) with atypical-appearing nuclei.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Photomicrograph shows immunohistochemically stained cells positive for S100 protein.

Graphic Jump Location




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 8

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics