Clinical Note |

Supraclavicular Lymphadenopathy Due to Silicone Breast Implants

Taha Z. Shipchandler, MD; Robert R. Lorenz, MD; James McMahon, PhD; Raymond Tubbs, DO
Arch Otolaryngol Head Neck Surg. 2007;133(8):830-832. doi:10.1001/archotol.133.8.830.
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Silicone prosthesis for either joints or plastic surgical procedures, specifically breast augmentation, has been documented to cause enlargement in local lymph node groups.1,2 Inflammatory reactions in foreign bodies containing silicone have been noted within fine-needle aspiration (FNA) and/or histopathologic specimens of enlarged lymph nodes in the setting of silicone breast implants. As the population of women who have received silicone breast implants becomes older, greater incidence of implant leakage is expected.3 As a result, more women may present with local lymphadenopathy caused by silicone foreign body reaction.

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A, Axial computed tomographic scan showing right-sided supraclavicular lymphadenopathy; B, hematoxylin-eosin stain of excised lymph nodes showing lipogranulomatous infiltrate with abundant vacuoles (original magnification ×20); and C, x-ray microanalysis showing evidence of a large amount of elemental silicon in the lymph node (C indicates carbon; Ca, calcium; P, phosphorus; S, sulfur; and Si, silicon).

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