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Clinical Note |

Adult Xanthogranuloma Causing Nasal Obstruction

Brian F. Worden, MD; Jose E. Barrera, MD; Sam P. Most, MD
Arch Otolaryngol Head Neck Surg. 2010;136(5):509-512. doi:10.1001/archoto.2010.44.
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Adult xanthogranuloma (AXG) is a rare histiocytic disease that produces predominantly cutaneous lesions. We describe a female patient with AXG who developed xanthogranulomatous lesions within the nasal vestibule, bilaterally producing progressive nasal obstruction. A septorhinoplasty with excision of the nasal xanthogranuloma was initially successful at improving her nasal obstruction. However, within weeks, regrowth of the lesion again began producing progressive narrowing of the nasal vestibules. A comprehensive review of the English-language literature revealed only 1 other case with this presentation in an adult.1 We discuss this interesting case and present a brief review of the disease process.

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Figure 1.

A, Preoperative photograph showing thickening of caudal septum and narrowing of nasal vestibule; B, postoperative photograph showing improved nasal airway.

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Figure 2.

Excised soft-tissue fragments from the caudal septum and the lateral vestibule.

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Figure 3.

Hematoxylin-eosin preparation showing a dense infiltration of histiocytes and inflammatory cells (original magnification ×10).

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Figure 4.

Hematoxylin-eosin preparation showing histiocytes and multinucleated giant cells (original magnification ×20).

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Adult xanthogranuloma causing nasal obstruction. Arch Otolaryngol Head Neck Surg 2010;136(5):509-12.
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