The parapharyngeal space (PPS) is a rare site for neoplasms in the head and neck, representing only 0.5% of head and neck tumors. Most commonly of parotid and neurogenic origin, tumors of the PPS are histologically diverse. Lipomas of the PPS are rare and liposarcomas rarer still. Only 5 liposarcomas of the PPS have been previously reported (Table). We describe our experience at the University of South Florida (USF), Tampa, with this unusual entity in this review of 2 lipomas, 1 pleomorphic liposarcoma, and 1 dedifferentiated liposarcoma of the PPS. To our knowledge, dedifferentiated liposarcoma has not previously been described in the PPS.
Case 1. T1-weighted magnetic resonance image of the neck demonstrating an extensive hyperintense parapharyngeal mass consistent with a lipomatous tumor.
Case 3. Large pleomorphic lipoblasts with bizarre, hyperchromatic nuclei demonstrating pleomorphic liposarcoma.
Case 4. A, Contrasted computed tomographic scan of the neck showing a large heterogenous lipogenic mass of the parapharyngeal space. B, Dedifferentiated areas resemble the storiform pattern of the malignant fibrous histiocytoma with the scattered pleomorphic multinucleated cells.
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