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CAVERNOUS SINUS THROMBOSIS:  REPORT OF RECOVERY FOLLOWING SULFAPYRIDINE THERAPY

LEWIS F. MORRISON, M.D.; MEYER SCHINDLER, M.D.
Arch Otolaryngol. 1940;31(6):948-954. doi:10.1001/archotol.1940.00660010963007.
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The subject of cavernous sinus thrombosis has been ably presented and discussed by various authors, notably by Dwight and Germain,1 Eagleton,2 Turner and Reynolds3 and Irish.4 It is the purpose of this paper to present data on a patient who recovered from cavernous sinus thrombosis and to give the details of therapy. Sulfapyridine was used as the chemotherapeutic agent.

Turner and Reynolds,3 like most authors, described acute and chronic forms of cavernous sinus thrombosis. The acute fulminating type has a high mortality. It spreads rapidly by direct extension, usually along the ophthalmic veins, traveling with, rather than against, the normal venous flow. The chronic type is more insidious in onset. The infection usually has its origin in the middle ear and gains entrance to the cavernous sinus by way of a retrograde thrombosis of the petrosal sinuses. Cavenagh5 pointed out that chronic thrombosis of the cavernous sinus has a lower

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