Among 792 patients treated for malignant diseases of the head and neck, 78 had adenocarcinoma (cylindroma, acinic cell, miscellaneous solid adenocarcinomas). The 63 determinate patients are reviewed. Adenocarcinoma was found frequently in women, in a younger age group, and in nonsmoking, nonalcoholics. Wide surgical excision was necessary and regional recurrence and distant metastases were common. Positive regional lymph nodes were sometimes present before any treatment. Radiation therapy was given to some persons postoperatively and was felt to be helpful, but not curative in cylindroma. Chemotherapy was not found helpful. There are 36 patients living without evidence of tumor from two to over ten years. Five patients died from other causes. Twenty-two patients died from their tumor, 15 within five years of diagnosis.