The pathogenesis of human salivary gland tumors and stones remains an enigma. Presently used model systems are not valid in light of known epidemiologic data. A large literature exists concerning the effects of the autonomic nervous system on salivary gland anatomy and physiology.
The present study was undertaken to see if stones or tumors could be induced In the salivary glands of rats subjected to long-term parenteral administration of isoproterenol. One-micron and electron microscopic evaluation demonstrated reversible acinar hyperplasia. No stones or tumors were found, even with the added stimulus of cyclophosphamide.