Regeneration of Nasal Skeletal Structures After Subperiosteal and Subperichondrial Resection:  Experimental Study in Adult Dogs

David A. Lee, MD; William K. Wright, MD
Arch Otolaryngol. 1977;103(5):281-283. doi:10.1001/archotol.1977.00780220075008.
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• The degree of regeneration of nasal structures after surgical resection was evaluated in six mongrel dogs that underwent selective resection of the nasal bones and upper lateral cartilages. Preservation of the periosteal and periochondrial flaps was accomplished during the resection. In several cases, different tissues were interposed between the flaps before their closure. The dogs were killed at two- and eight-month intervals after the original resections. No evidence of new cartilage regeneration was found on microscopic evaluation in the region of the resected upper lateral cartilages. Minimal new bone foci were noted at the edge of the resected nasal bones in three of the cases. The findings failed to support any significant degree of nasal structure regeneration after resection.

(Arch Otolaryngol 103:281-283, 1977)


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