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Lymphocyte Subsets in Normal Airway Mucosa of the Human Nose

Birgit Winther, MD; Donald J. Innes Jr, MD; Stacey E. Mills, MD; Niels Mygind, MD; Denise Zito; Frederick G. Hayden, MD
Arch Otolaryngol Head Neck Surg. 1987;113(1):59-62. doi:10.1001/archotol.1987.01860010063016.
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• The distribution and number of lymphocytes, monocytes/macrophages, and cells expressing HLA-DR antigen were studied in frozen biopsy sections of nasal mucosa from 40 healthy adults, using monoclonal antibody avidin-biotin immunoperoxidase techniques. The lymphocyte to monocyte/macrophage ratio was estimated to be 10:1; the T cell to B cell ratio was 3:1; and the T helper/inducer cell to T suppressor/cytotoxic cell ratio averaged 2.5:1. Regional differences were observed with a relatively increased number of T suppressor/cytotoxic cells around submucosal glands, and a relatively large number of B cells in lymphocyte aggregates in the lamina propria. The HLA-DR antigen was expressed in epithelial cells, suggesting involvement of surface epithelium of human airway in local immune responses.

(Arch Otolaryngol Head Neck Surg 1987;113:59-62)


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