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Efficacy of Defibrinogenation and Steroid Therapies on Sudden Deafness

Takeshi Kubo, MD; Tohru Matsunaga, MD; Hideyo Asai, MD; Kazutomo Kawamoto, MD; Jun Kusakari, MD; Yasuya Nomura, MD; Makoto Oda, MD; Noriyuki Yanagita, MD; Hideto Niwa, MD; Takuya Uemura, MD; Shizuo Komune, MD
Arch Otolaryngol Head Neck Surg. 1988;114(6):649-652. doi:10.1001/archotol.1988.01860180063031.
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• Effects of defibrinogenation therapy and steroid therapy for sudden deafness were compared by paired double-blind testing. The average hearing recovery for five frequencies (250 to 4000 Hz) was more than 30 dB; overall improvement rate was 57.3% (47/82) for the patients assigned to defibrinogenation therapy and 38.7% (31/80) for the patients assigned to steroid therapy. Thus, the former treatment resulted in significantly better hearing recovery.

(Arch Otolaryngol Head Neck Surg 1988;114:649-652)

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