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The Comparative Evaluation of Amoxicillin and Cefaclor in the Treatment of Acute Otitis Media With Effusion

Arch Otolaryngol Head Neck Surg. 1988;114(12):1367. doi:10.1001/archotol.1988.01860240017011.
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At the third annual meeting of the American Society of Pediatric Otolaryngology, Kiawah Island, SC, Dr Stanievich and colleagues, Children's Hospital, Buffalo, reported a study comparing amoxicillin to cefaclor (Ceclor) for the treatment of acute otitis media with effusion. Since cefaclor is resistant to β-lactamase inactivation, the study tried to determine if it is better than amoxicillin. Diagnosis was established by pneumatic otoscopy, tympanometry, audiometry when possible, tympanocentesis, and at least one of the following symptoms: fever, otalgia, and irritability. Response to treatment was based on resolving the middle ear effusion. Patients were randomized to one of the study groups. Ten days after initiation of therapy (40 mg/kg/d divided over three doses with a maximum of 1 g/d of cefaclor or amoxicillin) otoscopy, tympanometry, and audiometry were repeated. Treatment was repeated if effusion was present; otherwise, the patient received no further treatment. The children who took another ten-day course of


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