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Hydroxyapatite Cement II. Obliteration and Reconstruction of the Cat Frontal Sinus

Craig D. Friedman, MD; Peter D. Costantino, MD; Kent Jones, MD; Lawrence C. Chow, PhD; Harold J. Pelzer, DDS, MD; George A. Sisson Sr, MD
Arch Otolaryngol Head Neck Surg. 1991;117(4):385-389. doi:10.1001/archotol.1991.01870160039005.
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• Frontal sinus obliteration and reconstruction can be performed with autogenous grafts or synthetic implants, each of which has significant limitations. Hydroxyapatite cement, which can be shaped intraoperatively and sets to a microporous hydroxyapatite implant, was applied to this problem. Nine cats had the anterior table of their frontal sinus unilaterally removed and the sinus cavity stripped of its mucosa. Hydroxyapatite cement was used to obliterate the cavity and reconstruct the overlying anterior table defect. The unoperated side served as the control, and the animals were sacrificed up to 18 months postoperatively. There were no adverse reactions, infections, mucoceles, or implant extrusions.

The normal anatomic contour of the forehead region overlying the hydroxyapatite cement implants was maintained in all animals. Histologic examination of undecalcified whole sinus sections revealed progressive replacement of the implants with woven bone without a loss of volume. Replacement of the hydroxyapatite cement by woven bone is postulated to occur through a combination of implant resorption coupled with osteoconduction. The use of hydroxyapatite cement proved successful for the reconstruction and obliteration of cat frontal sinuses, and may be appropriate for the same application in humans.

(Arch Otolaryngol Head Neck Surg. 1991; 117:385-389)


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