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High-Frequency Monitoring for Early Detection of Cisplatin Ototoxicity

Stephen A. Fausti, PhD; James A. Henry, MS; Heidi I. Schaffer, MA; Deanna J. Olson, MS; Richard H. Frey; Grover C. Bagby Jr, MD
Arch Otolaryngol Head Neck Surg. 1993;119(6):661-666. doi:10.1001/archotol.1993.01880180081015.
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• Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (≥8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing.

(Arch Otolaryngol Head Neck Surg. 1993;119:661-666)

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