In the May 1990 issue of the Archives, Esposito et al1 have an article that defines the topical use of ciprofloxacin as three drops containing 250 μg/mL in saline solution locally twice a day. In the August 1992 issue Esposito et al2 again published another article whereby they propose the use of ciprofloxacin hydrochloride, four drops containing 250 mg/mL in saline solution administered locally twice a day. I am deeply concerned about this dosage difference and I would be more than happy if I can learn the exact dosage.
In our university hospital we are also conducting a study about the efficacy of topical ciprofloxacin in chronic otitis media. We apply ciprofloxacin hydrochloride, three drops containing 200 μg/mL in saline solution administered locally twice a day.