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The Use of Interferon Alfa-2a for Life-Threatening Hemangiomas

Carol J. MacArthur, MD; Craig W. Senders, MD; Jacob Katz, MD
Arch Otolaryngol Head Neck Surg. 1995;121(6):690-693. doi:10.1001/archotol.1995.01890060088018.
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Hemangiomas common benign neoplasm in the neonatal period. While most small hemangiomas involute spontaneously, up to 20% may grow to a massive size and never completely involute. Massive hemangiomas are also frequently associated with life-threatening complications, such as airway obstruction, platelet trapping (Kasabach-Merritt syndrome), and high-output heart failure. The use of interferon alfa-2a for the treatment of massive hemangiomas not responsive to traditional therapy has recently been reported. We present the successful use of interferon alfa-2a in a series of five patients with massive hemangiomas complicated by airway compromise, congestive heart failure, need for tracheotomy, Kasabach-Merritt syndrome, and failure to thrive, despite traditional therapy.

(Arch Otolaryngol Head Neck Surg. 1995;121:690-693)


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