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Clinical Note |

Subglottic Stenosis Secondary to Lymphoplasmacytic Lymphoma

Maria K. Brake, MD; Boyd S. Lee, MD, FRCSC; Benjamin J. A. Hoyt, MD; Mark Taylor, MD, FRCSC
Arch Otolaryngol Head Neck Surg. 2011;137(2):187-189. doi:10.1001/archoto.2010.253.
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Subglottic stenosis often presents a challenging problem for the otolaryngologist because its causes are many and varied, and its management is often difficult. The causes of adult-onset subglottic stenosis have been well documented and include trauma, collagen vascular diseases, benign and malignant neoplasms, and chronic inflammatory conditions.1 To our knowledge, we present the first successfully medically managed case of subglottic stenosis secondary to lymphoplasmacytic lymphoma (LPL), a malignant, infiltrative lymphoproliferative disorder of IgM producing monoclonal B lymphocytes. The clinical findings of LPL are commonly called Waldenstrom macroglobulinemia (WM).

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Figure 1.

Computed tomographic (CT) images. A, Axial CT with contrast demonstrating subglottic narrowing. B, Reformatted coronal image; arrows indicate the extent of the stenosis. C, Axial CT at the level of extensive nodal disease; arrows and braces indicate cervical lymphadenopathy.

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Figure 2.

Hematoxylin-eosin–stained specimen. Dense lymphoid infiltrate is evident in the dermis layer, consistent with skin involvement from lymphoplasmacytic lymphoma (original magnification approximately ×150; precise magnification information no longer available).

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Subglottic stenosis secondary to lymphoplasmacytic lymphoma. Arch Otolaryngol Head Neck Surg 2011;137(2):187-9.