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June 1982, Vol 108, No. 6 >
ARTICLE | June 1982

Immunoperoxidase Characterization of a Pharyngeal Plasmacytoma FREE

David M. Humphrey, MD; Thomas B. Aufdemorte, DDS; Douglas E. Mattox, MD
[+] Author Affiliations

Accepted for publication Jan 28, 1982.

Reprint requests to Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78284 (Dr Humphrey).


Arch Otolaryngol Head Neck Surg. 1982;108(6):362-365. doi:10.1001/archotol.1982.00790540034009
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References
Comments

• Extramedullary plasmacytomas (EMPs) are plasma cell neoplasms that most frequently arise along the upper airways and often do not secrete detectable amounts of M protein at the time of diagnosis. The present report describes the immunohistochemical characterization of an EMP in a young woman. The unlabeled peroxidase-antiperoxidase method was employed to demonstrate cytoplasmic immunoglobulin determinants in routinely processed, paraffin-embedded tissue. Only κ light chain and γ heavy chain determinants were found in the cytoplasm of the neoplastic plasma cells; essentially identical results were found in both initial and recurrent lesions separated by a 16-month interval. This exclusive staining of one light chain type associated with only one heavy chain represents a monoclonal staining pattern that is typical of B-cell neoplasms. Such characterization of EMPs on the basis of cytoplasmic immunoglobulin class and type may provide prognostic information analogous to the classification of multiple myeloma by immunoelectrophoresis.

(Arch Otolaryngol 1982;108:362-365)

REFERENCES

1 +
Batsakis JG, Fries GT, Goldman RT, et al:  Upper respiratory tract plasmacytoma . Arch Otolaryngol 1964;;79:613-618.
2 +
Castro EB, Lewis JS, Strong EW:  Plasmacytoma of paranasal sinuses and nasal cavity . Arch Otolaryngol 1973;;97:326-329.
3 +
Dolin S, Dewar JP:  Extramedullary plasmacytoma . Am J Pathol 1956;;32:83-103.
4 +
Ewing MR, Foot FW:  Plasma cell tumors of the mouth and upper air passages . Cancer 1952;;5:499-513.
5 +
Fu YS, Perzin KH:  Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: A clinicopathologic study: IX. Plasmacytomas . Cancer 1978;;42:2399-2406.
6 +
Hellwig CA:  Extramedullary plasma cell tumors as observed in various locations . Arch Pathol 1943;;36:95-111.
7 +
Poole AG, Marchetta FC:  Extramedullary plasmacytoma of the head and neck . Cancer 1968;;22:14-21.
8 +
Stout AP, Kenney FR:  Primary plasma-cell tumors of the upper air passages and oral cavity . Cancer 1949;;2:261-278.
9 +
Wiltshaw E:  The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis . Medicine 1976;;55:217-238.
10 +
Woodruff RK, Whittle JM, Malpas JS:  Solitary plasmacytoma: I. Extra-medullary soft tissue plasmacytoma . Cancer 1979;;43:2340-2343.
11 +
Magrath IT:  Lymphocyte differentiation: An essential basis for the comprehension of lymphoid neoplasia . JNCI 1981;;67:501-514.
12 +
Van den Tweel JG, Lukes RJ, Taylor CR:  Pathophysiology of lymphocyte transformation: A study of so-called composite lymphomas . Am J Clin Pathol 1979;;71:509-520.
13 +
Levy R, Warnke R, Dorfman RF, et al:  The monoclonality of human B-cell lymphomas . J Exp Med 1977;;145:1014-1028.
14 +
Warnke R, Levy R:  Immunopathology of follicular lymphomas: A model of B-lymphocyte homing . N Engl J Med 1978;;298:481-486.
15 +
Zulman J, Jaffe R, Talal N:  Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm . N Engl J Med 1978;;299:1215-1220.
16 +
Pinkus GS, Said JW:  Specific identification of intracellular immunoglobulin in paraffin sections of multiple myeloma and macroglobulinemia using an immunoperoxidase technique . Am J Pathol 1977;;87:47-58.
17 +
Taylor CR, Russell R, Chandor S:  An immunohistologic study of multiple myeloma and related conditions, using an immunoperoxidase method . Am J Clin Pathol 1978;;70:612-622.
18 +
Leonardo E, Palestro G, Stramignoni A:  Identification of rhinopharyngeal plasmacytic tumors by immunofluorescence on paraffinembedded sections . Oncology 1979;;36:89-93.
19 +
Scott FET, Dupont PA, Webb J:  Plasmacytoma of the stomach: Diagnosis with the aid of the immunoperoxidase technique . Cancer 1978;;41:675-681.
20 +
Conklin R, Alexanian R:  Clinical classification of plasma cell myeloma . Arch Intern Med 1975;;135:139-143.
21 +
Jancelewicz Z, Takatsuki K, Sugai S, et al:  IgD multiple myeloma: Review of 133 cases . Arch Intern Med 1975;;135:87-93.
22 +
Sternberger LA: Immunochemistry . New York, John Wiley & Sons Inc, 1979;.
23 +
Aufdemorte TB, Humphrey DM:  Immunoperoxidase characterization of a malignant plasma cell tumor involving the mandible . J Oral Surg , to be published.
24 +
Humphrey DM, Cortez EA, Spiva DA:  Immunohistologic studies of cytoplasmic immunoglobulins in rheumatic diseases including two patients with monoclonal patterns and subsequent lymphoma . Cancer , to be published.
25 +
Corwin J, Lindberg RD:  Solitary plasmacytoma of bone vs extramedullary plasmacytoma and their relationship to multiple myeloma . Cancer 1979;;43:1007-1013.
26 +
Hobbs JR:  Immunocytoma o' mice an' men . Br Med J 1971;;10:67-72.
27 +
Hobbs JR:  Monitoring myelomatosis . Arch Intern Med 1975;;135:125-130.
28 +
Maruyama Y, Thomson J:  Radiotherapeutic response of plasma cell tumors associated with monoclonal gammopathy . Cancer 1970;;26:110-113.

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1 +
Batsakis JG, Fries GT, Goldman RT, et al:  Upper respiratory tract plasmacytoma . Arch Otolaryngol 1964;;79:613-618.
2 +
Castro EB, Lewis JS, Strong EW:  Plasmacytoma of paranasal sinuses and nasal cavity . Arch Otolaryngol 1973;;97:326-329.
3 +
Dolin S, Dewar JP:  Extramedullary plasmacytoma . Am J Pathol 1956;;32:83-103.
4 +
Ewing MR, Foot FW:  Plasma cell tumors of the mouth and upper air passages . Cancer 1952;;5:499-513.
5 +
Fu YS, Perzin KH:  Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: A clinicopathologic study: IX. Plasmacytomas . Cancer 1978;;42:2399-2406.
6 +
Hellwig CA:  Extramedullary plasma cell tumors as observed in various locations . Arch Pathol 1943;;36:95-111.
7 +
Poole AG, Marchetta FC:  Extramedullary plasmacytoma of the head and neck . Cancer 1968;;22:14-21.
8 +
Stout AP, Kenney FR:  Primary plasma-cell tumors of the upper air passages and oral cavity . Cancer 1949;;2:261-278.
9 +
Wiltshaw E:  The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis . Medicine 1976;;55:217-238.
10 +
Woodruff RK, Whittle JM, Malpas JS:  Solitary plasmacytoma: I. Extra-medullary soft tissue plasmacytoma . Cancer 1979;;43:2340-2343.
11 +
Magrath IT:  Lymphocyte differentiation: An essential basis for the comprehension of lymphoid neoplasia . JNCI 1981;;67:501-514.
12 +
Van den Tweel JG, Lukes RJ, Taylor CR:  Pathophysiology of lymphocyte transformation: A study of so-called composite lymphomas . Am J Clin Pathol 1979;;71:509-520.
13 +
Levy R, Warnke R, Dorfman RF, et al:  The monoclonality of human B-cell lymphomas . J Exp Med 1977;;145:1014-1028.
14 +
Warnke R, Levy R:  Immunopathology of follicular lymphomas: A model of B-lymphocyte homing . N Engl J Med 1978;;298:481-486.
15 +
Zulman J, Jaffe R, Talal N:  Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm . N Engl J Med 1978;;299:1215-1220.
16 +
Pinkus GS, Said JW:  Specific identification of intracellular immunoglobulin in paraffin sections of multiple myeloma and macroglobulinemia using an immunoperoxidase technique . Am J Pathol 1977;;87:47-58.
17 +
Taylor CR, Russell R, Chandor S:  An immunohistologic study of multiple myeloma and related conditions, using an immunoperoxidase method . Am J Clin Pathol 1978;;70:612-622.
18 +
Leonardo E, Palestro G, Stramignoni A:  Identification of rhinopharyngeal plasmacytic tumors by immunofluorescence on paraffinembedded sections . Oncology 1979;;36:89-93.
19 +
Scott FET, Dupont PA, Webb J:  Plasmacytoma of the stomach: Diagnosis with the aid of the immunoperoxidase technique . Cancer 1978;;41:675-681.
20 +
Conklin R, Alexanian R:  Clinical classification of plasma cell myeloma . Arch Intern Med 1975;;135:139-143.
21 +
Jancelewicz Z, Takatsuki K, Sugai S, et al:  IgD multiple myeloma: Review of 133 cases . Arch Intern Med 1975;;135:87-93.
22 +
Sternberger LA: Immunochemistry . New York, John Wiley & Sons Inc, 1979;.
23 +
Aufdemorte TB, Humphrey DM:  Immunoperoxidase characterization of a malignant plasma cell tumor involving the mandible . J Oral Surg , to be published.
24 +
Humphrey DM, Cortez EA, Spiva DA:  Immunohistologic studies of cytoplasmic immunoglobulins in rheumatic diseases including two patients with monoclonal patterns and subsequent lymphoma . Cancer , to be published.
25 +
Corwin J, Lindberg RD:  Solitary plasmacytoma of bone vs extramedullary plasmacytoma and their relationship to multiple myeloma . Cancer 1979;;43:1007-1013.
26 +
Hobbs JR:  Immunocytoma o' mice an' men . Br Med J 1971;;10:67-72.
27 +
Hobbs JR:  Monitoring myelomatosis . Arch Intern Med 1975;;135:125-130.
28 +
Maruyama Y, Thomson J:  Radiotherapeutic response of plasma cell tumors associated with monoclonal gammopathy . Cancer 1970;;26:110-113.

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