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ARTICLE |

Cardiopulmonary Arrest due to Misuse of Viscous Lidocaine FREE

Mark S. Puczynski, MD; Earl Phillip Ow, MD; Cynthia Rust, MD
[+] Author Affiliations

Accepted for publication May 13, 1985.

Reprint requests to Loyola University Medical Center, Room 4671, 2160 S First Ave, Maywood, IL 60153 (Dr Puczynski).


Arch Otolaryngol Head Neck Surg. 1985;111(11):768-769. doi:10.1001/archotol.1985.00800130100015
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• A 30-month-old female infant had a cardiopulmonary arrest due to viscous lidocaine. The protective airway mechanisms were blunted by this drug, resulting in aspiration, hypoxia, seizures, and death. Lidocaine has also been associated with respiratory depression, psychosis, methemoglobinemia, and toxic cardiovascular reactions. We do not recommend the use of viscous lidocaine for minor oral irritation in infants and young children.

(Arch Otolaryngol 1985;111:768-769)

REFERENCES

Demczuk RJ:  Significant sinus bradycardia following intravenous lidocaine injection . Anesthesiology 1984;;60:69-70.
Antonelli D, Ben Ami M, Weiss Z:  Sinus standstill following accidental lidocaine overdose . Am Heart J 1984;;107:1042-1044.
Hill GJ:  Lidocaine asystole . JAMA 1973;; 224:401.
Afano SN, Leicht MJ, Skiendzielewski JJ:  Lidocaine toxicity following subcutaneous administration . Ann Emerg Med 1984;;13:465-467.
Boyes RN, Scott DB, Jebson PJ, et al:  Pharmacokinetics of lidocaine in man . Clin Pharmacol Ther 1971;;12:105-115.
Strong JM, Mayfield DE, Atkinson AJ, et al:  Pharmacological activity, metabolism and pharmacokinetics of glycinexylidide . Clin Pharmacol Ther 1975;;17:184-194.
O'Donohue WJ, Moss LM, Angelillo VA:  Acute methemoglobinemia induced by topical benzocaine and lidocaine . Arch Intern Med 1980;; 140:1508-1509.
Mofensen HC, Caraccio TR, Miller H, et al:  Lidocaine toxicity from topical mucosal application . Clin Pediatr 1983;;22:190-192.
Rothstein P, Cornbusch J, Shaywitz BA:  Prolonged seizures associated with the use of viscous lidocaine . J Pediatr 1982;;101:461-463.

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Demczuk RJ:  Significant sinus bradycardia following intravenous lidocaine injection . Anesthesiology 1984;;60:69-70.
Antonelli D, Ben Ami M, Weiss Z:  Sinus standstill following accidental lidocaine overdose . Am Heart J 1984;;107:1042-1044.
Hill GJ:  Lidocaine asystole . JAMA 1973;; 224:401.
Afano SN, Leicht MJ, Skiendzielewski JJ:  Lidocaine toxicity following subcutaneous administration . Ann Emerg Med 1984;;13:465-467.
Boyes RN, Scott DB, Jebson PJ, et al:  Pharmacokinetics of lidocaine in man . Clin Pharmacol Ther 1971;;12:105-115.
Strong JM, Mayfield DE, Atkinson AJ, et al:  Pharmacological activity, metabolism and pharmacokinetics of glycinexylidide . Clin Pharmacol Ther 1975;;17:184-194.
O'Donohue WJ, Moss LM, Angelillo VA:  Acute methemoglobinemia induced by topical benzocaine and lidocaine . Arch Intern Med 1980;; 140:1508-1509.
Mofensen HC, Caraccio TR, Miller H, et al:  Lidocaine toxicity from topical mucosal application . Clin Pediatr 1983;;22:190-192.
Rothstein P, Cornbusch J, Shaywitz BA:  Prolonged seizures associated with the use of viscous lidocaine . J Pediatr 1982;;101:461-463.

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