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Clinical Scoring System in the Evaluation of Adult Pharyngitis FREE

Helena Seppälä, MD; Riitta Lahtonen, MD; Thedi Ziegler, PhD; Olli Meurman, MD; Kati Hakkarainen, MD; Ari Miettinen, MD; Pertti Arstila, MD; Jussi Eskola, MD; Pekka Saikku, MD; Pentti Huovinen, MD
[+] Author Affiliations

Accepted for publication October 9, 1992.

Reprint requests to Antimicrobial Research Laboratory, National public Health Institute, PO Box 57, 20521 Turku, Finland (Dr Seppälä).


Arch Otolaryngol Head Neck Surg. 1993;119(3):288-291. doi:10.1001/archotol.1993.01880150036006
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• Objective.  —To compare results of a clinical scoring system for diagnosis of group A streptococcal pharyngitis with microbiologic results, when several different pharyngeal pathogens were tested simultaneuously.

Design.  —Evaluation of clinical manifestations of 106 adult patients with pharyngitis of different microbial origin.

Setting.  —General private practice; Health Center Pulssi, Turku, Finland.

Patients.  —Adult patients whose chief complaints were sore throats.

Main Outcome Measure.  —A symptom score that was assigned to each patient according to the total number of certain signs and symptoms that are postulated to increase the probability of group A streptococcal pharyngitis and blood measurements for infection.

Results.  —The highest symptom scores, 3 and 4, were found in 21 patients. These patients had pharyngitis due to group A streptococcus (four patients), group C streptococcus (four patients), group G streptococcus (two patients), group F streptococcus, Mycoplasma pneumoniae, Chlamydia pneumoniae, influenza A virus, influenza B virus, herpes simplex type 1 virus (two patients), and coxsackie B4 virus. No pathogen could be identified from three of the 21 patients. The C-reactive protein values and the leukocyte counts were raised significantly more often in streptococcal infections than in infections of other origin; the P values were.00016 and.028, respectively.

Conclusion.  —Use of a clinical scoring system alone for diagnosis of pharyngitis may lead to improper use of antimicrobial agents. There is a need for accurate microbiologic diagnostic procedures in general practice to determine proper treatment of pharyngitis as well as to test the effect of antibacterial and, in the future, antiviral treatment in respiratory tract infections.(Arch Otolaryngol Head Neck Surg. 1993;119:288-291)

REFERENCES

Komaroff AL, Pass TM, Aronson MD, et al.  The prediction of streptococcal pharyngitis in adults . J Gen Intern Med. 1986;;1:1-7.
Centor RM, Meier FA, Dalton HP.  Throat cultures and rapid tests for diagnosis for group A streptococcal pharyngitis . Ann Intern Med. 1986;;105: 892-899.
Huovinen P, Lahtonen R, Ziegler T, et al.  Pharyngitis in adults: the presence and coexistence of viruses and bacterial organisms . Ann Intern Med. 1989;;110:612-616.
Glezen WP, Clyde WA Jr, Senior RJ, Sheaffer CI, Denny FW.  Group A streptococci, mycoplasmas and viruses associated with acute pharyngitis . JAMA . 1967;;202:455-460.
Evans AS, Dick EC.  Acute pharyngitis and tonsillitis in University of Wisconsin students . JAMA . 1964;;190:699-708.
Komaroff AL, Aronson MD, Pass TM, Ervin CT, Branch WT Jr.  Serologic evidence of chlamydial and mycoplasmal pharyngitis in adults . Science . 1983;;222:927-929.
Saikku P, Mattila K, Nieminen MS, et al.  Serological evidence of an association of a novel Chlamydia TWAR, with chronic coronary heart disease and acute myocardial infarction . Lancet . 1988;;2:983-986.
Poses RM, Cebul RD, Collin M, Fager SS.  The accuracy of experienced physicians' probability estimates for patients with sore throat . JAMA . 1985;; 254:925-929.
Walsh BT, Bookheim WW, Johnson RC, Tompkins RK.  Recognition of streptococcal pharyngitis in adults . Arch Intern Med. 1975;;135:1493-1497.
Tompkins RK, Burnes DC, Cable WE.  An analysis of cost-effectiveness of pharyngitis management and acute rheumatic fever prevention . Ann Intern Med. 1977;;86:481-492.
Grawford G, Brancato F, Holmes KK.  Streptococcal pharyngitis: diagnosis by Gram stain . Ann Intern Med. 1979;;90:293-297.
Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K.  The diagnosis of strep throat in adults in the emergency room . Med Decis Making . 1981;;3:239-246.
Schachtel BP, Fillingim JM, Beiter DJ, Lane AC, Schwartz LA.  Subjective and objective features of sore throat . Arch Intern Med. 1984;;144:497-500.
Reed BD, Huck W, French T.  Diagnosis of group A β-hemolytic streptococcus using clinical scoring criteria, directing 1-2-3 group A streptococcal test, and culture . Arch Intern Med. 1990;;150:1727-1732.
Meier FA, Centor RM, Graham L, Dalton HP.  Clinical and microbiological evidence for endemic pharyngitis among adults due to group C streptococci . Arch Intern Med. 1990;;150:825-829.
Roos K.  The diagnostic value of symptoms and signs in acute tonsillitis in children over the age of 10 and in adults . Scand J Infect Dis. 1985;;17: 259-267.

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Komaroff AL, Pass TM, Aronson MD, et al.  The prediction of streptococcal pharyngitis in adults . J Gen Intern Med. 1986;;1:1-7.
Centor RM, Meier FA, Dalton HP.  Throat cultures and rapid tests for diagnosis for group A streptococcal pharyngitis . Ann Intern Med. 1986;;105: 892-899.
Huovinen P, Lahtonen R, Ziegler T, et al.  Pharyngitis in adults: the presence and coexistence of viruses and bacterial organisms . Ann Intern Med. 1989;;110:612-616.
Glezen WP, Clyde WA Jr, Senior RJ, Sheaffer CI, Denny FW.  Group A streptococci, mycoplasmas and viruses associated with acute pharyngitis . JAMA . 1967;;202:455-460.
Evans AS, Dick EC.  Acute pharyngitis and tonsillitis in University of Wisconsin students . JAMA . 1964;;190:699-708.
Komaroff AL, Aronson MD, Pass TM, Ervin CT, Branch WT Jr.  Serologic evidence of chlamydial and mycoplasmal pharyngitis in adults . Science . 1983;;222:927-929.
Saikku P, Mattila K, Nieminen MS, et al.  Serological evidence of an association of a novel Chlamydia TWAR, with chronic coronary heart disease and acute myocardial infarction . Lancet . 1988;;2:983-986.
Poses RM, Cebul RD, Collin M, Fager SS.  The accuracy of experienced physicians' probability estimates for patients with sore throat . JAMA . 1985;; 254:925-929.
Walsh BT, Bookheim WW, Johnson RC, Tompkins RK.  Recognition of streptococcal pharyngitis in adults . Arch Intern Med. 1975;;135:1493-1497.
Tompkins RK, Burnes DC, Cable WE.  An analysis of cost-effectiveness of pharyngitis management and acute rheumatic fever prevention . Ann Intern Med. 1977;;86:481-492.
Grawford G, Brancato F, Holmes KK.  Streptococcal pharyngitis: diagnosis by Gram stain . Ann Intern Med. 1979;;90:293-297.
Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K.  The diagnosis of strep throat in adults in the emergency room . Med Decis Making . 1981;;3:239-246.
Schachtel BP, Fillingim JM, Beiter DJ, Lane AC, Schwartz LA.  Subjective and objective features of sore throat . Arch Intern Med. 1984;;144:497-500.
Reed BD, Huck W, French T.  Diagnosis of group A β-hemolytic streptococcus using clinical scoring criteria, directing 1-2-3 group A streptococcal test, and culture . Arch Intern Med. 1990;;150:1727-1732.
Meier FA, Centor RM, Graham L, Dalton HP.  Clinical and microbiological evidence for endemic pharyngitis among adults due to group C streptococci . Arch Intern Med. 1990;;150:825-829.
Roos K.  The diagnostic value of symptoms and signs in acute tonsillitis in children over the age of 10 and in adults . Scand J Infect Dis. 1985;;17: 259-267.

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