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 Showing 1-20 of 42 Articles
Original Investigation 
Robert C. O’Reilly, MD; Sam Soundar, PhD; Dalal Tonb, ScD; Laura Bolling, BS; Estelle Yoo, MD; Tracey Nadal, BS; Christopher Grindle, MD; Erin Field, PA; Zhaoping He, PhD

Importance  Otitis media is characterized as an ongoing inflammation with accumulation of an effusion in the middle ear cleft. The molecular mechanisms underlying the pathogenesis, particularly the inflammatory response, remain largely unknown. We hypothesize that aspiration of gastric contents into the nasopharynx may be responsible for the ...

Original Investigation 
Samir H. Patel, MD; Richard E. Hayden, MD; Michael L. Hinni, MD; William W. Wong, MD; Robert L. Foote, MD; Shadi Milani, BS; Qing Wu, ScD; Stephen J. Ko, MD; Michele Y. Halyard, MD

Importance  The etiology and optimal treatment are unknown for angiosarcoma, an aggressive malignant tumor that affects vascular endothelial cells and can be mistaken for benign lesions such as hemangioma.

Objective  To determine the treatment outcomes of patients with angiosarcoma of the face or scalp treated with ...

Original Investigation 
Neil Bhattacharyya, MD; Elliot Abemayor, MD, PhD

Importance  The care of patients with head and neck cancer (HNCA) is becoming increasingly regionalized to high-volume, more effective centers. However, it remains uncertain whether such care is equally distributed. Increasing our understanding of how HNCA treatment is utilized among different sectors should improve strategy designs aimed ...

Case Report/Case Series 
Christopher R. Kieliszak, DO; Amarbir Gill, BS; Mohammed Faiz, MD; Arjun S. Joshi, MD

Importance  Submandibular fistula is a rare condition that presents diagnostic and treatment challenges. Accurate diagnosis may be achieved by means of thorough physical examination, proper imaging, and usually surgical exploration. We describe the clinical significance of aberrant submandibular ductal fistula or ostium and discuss our dilemmas during ...

Original Investigation  FREE
Margaret T. Dillon, AuD; Oliver F. Adunka, MD; Meredith L. Anderson, AuD; Marcia C. Adunka, AuD; English R. King, AuD; Craig A. Buchman, MD; Harold C. Pillsbury, MD

Importance  This study reviewed whether advanced age should be a consideration when revision cochlear implantation is warranted.

Objective  To examine whether age at revision cochlear implantation is related to postrevision speech perception performance.

Design, Setting, and Participants  A retrospective analysis was performed in an academic ...

Original Investigation 
Adrian J. Priesol, MD; Mengfei Cao, BA; Carla E. Brodley, PhD; Richard F. Lewis, MD
Includes: Supplemental Content

Importance  Dizziness and imbalance are common clinical problems, and accurate diagnosis depends on determining whether damage is localized to the peripheral vestibular system. Vestibular testing guides this determination, but the accuracy of the different tests is not known.

Objective  To determine how well each element of ...

Original Investigation 
Scott A. Infusino, BA; Gillian R. Diercks, MD; Derek J. Rogers, MD; Jordan Garcia, BS; Shilpa Ojha, MBChB, MRCS, DO-HNS; Rie Maurer, MA; Glenn Bunting, MS, CCC-SLP; Christopher J. Hartnick, MD, MS
Includes: Supplemental Content

Importance  Few studies have used objective measures to evaluate the development of the normal pediatric voice. Cepstral analysis of continuous speech samples is a reliable method for gathering acoustic data; however, it has not been used to examine the changes that occur with voice development.

Objective  ...

Original Investigation 
Michael A. Kohanski, MD, PhD; Andrew P. Lane, MD
Includes: Supplemental Content

Importance  Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and paranasal sinuses. Staphylococcus aureus is increasingly linked with CRS exacerbations. Little is known about how bacteria activate inflammatory pathways that contribute to CRS.

Objective  To develop an in vitro coculture system to explore how ...

Clinical Challenge 
Ashley E. Kita, BS; Sunita M. Bhuta, MD; Marilene B. Wang, MD
A woman in her 50s presented with an 8-week history of increasing headache, hyposmia, hypogeusia, and nasal congestion. Endoscopic nasopharyngoscopy revealed a large polypoid nasal mass occupying the left nasal roof and completely obstructing the nasal passage. Contrast-enhanced T1-weighted magnetic resonance imaging revealed a soft-tissue mass within the left ethmoid ...
Original Investigation 
Carrie E. Flanagan, MD; Sarah K. Wise, MD, MSCR; John M. DelGaudio, MD; Zara M. Patel, MD

Importance  Seasonal influenza causes significant morbidity and mortality, with cardiovascular and respiratory complications the most common among susceptible individuals. Upper respiratory tract infections (URIs) are known to precede olfactory dysfunction in some patients. To our knowledge, there has been no study assessing the possible relationship between influenza ...

Original Investigation 
Chen-Chi Wang, MD; Ming-Hong Chang, MD; Rong-San Jiang, MD, PhD; Hsiu-Chin Lai, SLP; Armando De Virgilio, MD; Ching-Ping Wang, MD; Shang-Heng Wu, MD; Shi-An Liu, MD, PhD; Kai-Li Liang, MD
Includes: Supplemental Content

Importance  Unilateral vocal fold paralysis (UVFP) is a common voice disorder that may cause glottal closure insufficiency with hoarseness of voice. Laryngeal electromyography (LEMG)-guided hyaluronic acid vocal fold (VF) injection has been proposed as a treatment option to improve glottal closure with a satisfactory short-term effect. To ...

Clinical Problem Solving 
David S. Bick, MD; John J. Brockland, BS, MS; Andrew R. Scott, MD
In this case report, a 6-month-old girl has presented with a lesion at the midline vertex of her skull that had been present since birth. The lesion was noted to have an annular dark tuft of hair with central clearing emanating from an underlying plaque directly over the posterior fontanel. ...
Clinical Problem Solving 
Nathan Eivaz, BS; Vatsal Patel, MD; William O. Collins, MD
Original Investigation 
Kang Mei Chen, MD; Josena K. Stephen, MD; Shaleta Havard, AuD; Meredith Mahan, MS; George Divine, PhD; Maria J. Worsham, PhD
Includes: Supplemental Content

Importance  Human papillomavirus (HPV) is a known causative agent for oropharyngeal squamous cell carcinoma (OPSCC). Whereas it is becoming more firmly established that HPV-positive head and neck squamous cell carcinoma is associated with better survival outcomes, believed to be because of better response to chemoradiation therapy, the ...

Case Report/Case Series 
Daniel Demesh, MD; Jordan M. Virbalas, MD; John P. Bent, MD

Importance  Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) in children describes neuropsychiatric symptom exacerbations that relate temporally to streptococcal infections. Recent case reports suggest tonsillectomy may effectively reduce these symptoms; however, no consensus treatment guidelines exist. This study examines whether tonsillectomy improves neuropsychiatric symptoms in ...

Clinical Problem Solving 
Deepa Danan, MD, MBA; Yunchuan D. Mo, MD; David C. Shonka Jr, MD
A woman in her 40s presented with progressive dyspnea and inability to lie flat. Two years prior to presentation, she had noticed tender, firm thyroid enlargement associated with rapid weight gain. Computed tomography without contrast at the time of presentation demonstrated tracheal narrowing to 1.56 mm. Tracheostomy was recommended. Intraoperatively, ...
Original Investigation 
Timothy Cooper, MD; Vincent L. Biron, MD, PhD, FRCSC; Ben Adam, MD; Alexander C. Klimowicz, PhD; Lakshmi Puttagunta, MD, FRCPC; Hadi Seikaly, MD, FRCSC

Importance  Keratinization is a histologic feature on hematoxylin-eosin staining associated with adverse outcomes in head and neck cancer, particularly oral cavity squamous cell carcinoma. However, the prognostic value of keratinization has not been demonstrated in oropharyngeal squamous cell carcinoma (OPSCC) in a large cohort of patients.


Original Investigation 
Conan Liang, BA; Amanda G. Ruiz, BA; Emily L. Jensen, BS; Norman R. Friedman, MD, DABSM

Importance  Children undergoing urgent adenotonsillectomy have been poorly described in literature.

Objective  To characterize the clinical course and outcomes of patients who underwent urgent adenotonsillectomy.

Design, Setting, and Participants  A 7-year retrospective medical record review of patients undergoing urgent adenotonsillectomy (study group) at a tertiary ...

David W. Cuthbertson, MD; Nikhila Raol, MD; John Hicks, MD, DDS, PhD; Linda Green, MD; Robert Parke, MD

Importance  Basal cell adenocarcinoma (BCAC) of the minor salivary gland is an extremely rare disease: the most recent substantive literature review reports only 25 cases. Owing to the rarity of this disease, it has not yet been well characterized in the literature.

Objective  We sought to ...

Clinical Problem Solving 
Patricia Purcell, MD; Tanya Meyer, MD; Clint Allen, MD
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