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 Showing 1-20 of 39 Articles
Case Report/Case Series 
Jordan P. Sand, MD; Bruce H. Haughey, MBChB; Brian Nussenbaum, MD

Importance  The rapid increase of human papillomavirus–associated oropharyngeal cancer has demonstrated a need for new strategies in prevention, diagnosis, evaluation, and treatment. Because there are currently no available screening technologies to detect early disease, a trend of purely incidentally identified asymptomatic p16-positive squamous cell carcinoma has been ...

Original Investigation 
Luke Rudmik, MD, MSc; Kristine A. Smith, MD; Zachary M. Soler, MD, MSc; Rodney J. Schlosser, MD; Timothy L. Smith, MD, MPH

Importance  Idiopathic olfactory loss is a common clinical scenario encountered by otolaryngologists. While trying to allocate limited health care resources appropriately, the decision to obtain a magnetic resonance imaging (MRI) scan to investigate for a rare intracranial abnormality can be difficult.

Objective  To evaluate the cost-effectiveness ...

Original Investigation 
Marina Tsaoussoglou, PhD, MSc; Souzana Hatzinikolaou, MD; George E. Baltatzis, PhD; Loukia Lianou, MD; Panagiotis Maragozidis, MSc; Nikolaos A. A. Balatsos, PhD, MSc; George Chrousos, MD; Athanasios G. Kaditis, MD
Includes: Supplemental Content

Importance  Cysteinyl leukotrienes (CysLTs) potentially promote adenotonsillar hypertrophy in children with obstructive sleep apnea (OSA). Previous studies have identified CysLTs and their receptors in tonsillar tissue from children with OSA.

Objective  To demonstrate expression of the leukotriene biosynthetic enzymes 5-lipoxygenase (5-LO), 5-lipoxygenase activating protein (FLAP), leukotriene ...

Clinical Problem Solving 
Tristan C. Bice, BA; Ryan D. Walker, MD; Li-Xing Man, MSc, MD, MPA
Original Investigation 
Peter F. Svider, MD; Amar Gupta, MD; Andrew P. Johnson, MD; Giancarlo Zuliani, MD; Mahdi A. Shkoukani, MD; Jean Anderson Eloy, MD; Adam J. Folbe, MD

Importance  Prior to applying or interviewing, most prospective applicants turn to the Internet when evaluating residency programs, making maintenance of a comprehensive website critical. While certain “intangibles” such as reputation may not be communicated effectively online, residency websites are invaluable for conveying other aspects of a program. ...

Original Investigation 
Adam Hauch, MD, MBA; Zaid Al-Qurayshi, MBChB, MPH; Paul Friedlander, MD; Emad Kandil, MD

Importance  For the management of thyroid diseases, there have been few studies aimed at examining the association between disparities and outcomes.

Objective  To measure the effects of race, ethnicity, and socioeconomic status on outcomes following thyroid surgery.

Design, Setting, and Participants  Cross-sectional analysis of 62 722 ...

Original Investigation 
Bree Erickson, MD; Timothy Cooper, MD; Hamdy El-Hakim, FRCS (ORL-HNS)

Importance  The classic presentation of laryngomalacia (LM) is stridor, but alternate presentations include snoring and/or sleep-disordered breathing (S-SDB) and swallowing dysfunction (SWD). Several classification schemes have been developed for LM, but to our knowledge, none have been successfully investigated as to the ability to predict parameters of ...

Clinical Problem Solving 
Michael G. Taggart, BS; David J. Crockett, MD; Jeremy D. Meier, MD; Richard H. Wiggins III, MD
Clinical Problem Solving 
Suzanne E. Smart, MD; Tyler Crosby, BS; Anita Jeyakumar, MD, MS
Original Investigation 
Ian Smillie, MRCS Ed; Sophie Robertson; Anna Yule; David M. Wynne, FRCS; Craig J. H. Russell, FRCS

Importance  Optimizing hearing in patients with cleft lip and/or palate (CLP) by early recognition and management of otitis media with effusion is essential for speech development. Some evidence has suggested higher complication rates from ventilation tube (VT) insertion in patients with CLP and has led to a ...

Original Investigation 
Taylor S. Pence, BS; Evan R. Reiter, MD; Laurence J. DiNardo, MD; Richard M. Costanzo, PhD

Importance  Normal olfaction provides essential cues to allow early detection and avoidance of potentially hazardous situations. Thus, patients with impaired olfaction may be at increased risk of experiencing certain hazardous events such as cooking or house fires, delayed detection of gas leaks, and exposure to or ingestion ...

Original Investigation 
Darrin V. Bann, PhD; Neerav Goyal, MD, MPH; Fabian Camacho, MA, MS; David Goldenberg, MD

Importance  The incidence of thyroid cancer in the United States has increased rapidly and Pennsylvania is the state with the highest rate of thyroid cancer in the country, although the factors driving this increase are unknown. Moreover, it remains unclear whether the increase in thyroid cancer represents ...

Original Investigation 
Antoine Eskander, MD, ScM; Karen A. Gordon, PhD; Yamilet Tirado, MD, FACS; Talar Hopyan, PhD; Laurie Russell, MHSc, SLP(C), Reg CASLPO; Jennifer Allegro, MSc, SLP(C), Reg CASLPO; Blake C. Papsin, MD, MSc, FRCSC; Paolo Campisi, MSc, MD, FRCSC

Importance  Although voice has been studied extensively in children who use cochlear implants (CIs), speech production has not been studied in this population using the Motor Speech Profile. Whether children who receive CIs gain normal speech production abilities is unknown.

Objective  To assess speech and articulation ...

Original Investigation  FREE
Alison Maresh, MD; Diego A. Preciado, MD, PhD; Ashley P. O’Connell, BA, BS; George H. Zalzal, MD

Importance  Minimally invasive endoscopic techniques are an appealing alternative to open surgical management of pediatric subglottic stenosis (SGS), but more information is needed to understand the comparative risks, benefits, and limitations of such interventions.

Objective  To compare the effectiveness of endoscopic balloon dilation (EBD) and laryngotracheoplasty ...

Case Report/Case Series 
Alice E. Chang, MD; Bryan T. Ambro, MD; Scott E. Strome, MD; John C. Papadimitriou, MD, PhD; Kevin D. Pereira, MD, MS

Importance  Noncongenital immature teratomas in the head and neck are extremely rare, and to our knowledge have not previously been reported in the maxillary sinus of a pediatric patient.

Observations  Teratomas are neoplasms that contain tissue from more than 1 embryonic cell layer that is foreign ...

Original Investigation 
Andrew Thamboo, BSc, MHSc, MD; Rachelle C. Dar Santos, BSc; Lalenthra Naidoo, MBBCh, DCH, MMed(ORL); Ronak Rahmanian, BSc, MD; Mark A. Chilvers, MD, FRCPC; Neil K. Chadha, MBChB(Hons), MPHe, BSc(Hons), FRCS(ORL-HNS)

Importance  Sinonasal disease and, specifically, nasal polyps, occur frequently in children with cystic fibrosis (CF). As survival rates have improved, it has become imperative that otolaryngologists become involved in the care of patients with CF to provide appropriate medical and surgical interventions for sinonasal disease. Despite significant ...

Original Investigation 
Alexander T. Hillel, MD; Daryan Namba, BS; Dacheng Ding, MD, PhD; Vinciya Pandian, PhD; Jennifer H. Elisseeff, PhD; Maureen R. Horton, MD

Importance  Laryngotracheal stenosis (LTS) lacks an ideal animal model to study its unique wound-healing pathophysiology and the effect of interventions.

Objective  To present an in vivo, in situ mouse model of LTS that can be used to investigate its pathophysiology, mechanisms, and interventions for treatment.

Design, ...

Original Investigation 
Uchechukwu C. Megwalu, MD, MPH; Andrew G. Sikora, MD, PhD

Importance  Chemoradiation therapy has become increasingly popular in the treatment of advanced laryngeal cancer as part of an organ preservation protocol. However, several studies have reported a decline in survival, possibly attributable to the increased use of radiation and chemoradiation therapy.

Objective  To evaluate survival outcomes ...

Clinical Problem Solving 
Antonio Greco, MD, PhD; Giannicola Iannella, MD; Mario Tombolini, MD; Andrea Gallo, MD; Massimo Fusconi, MD, PhD; Marco de Vincentiis, MD
Clinical Problem Solving 
Andria M. Caruso, MD; Tanya K. Meyer, MD; Clint T. Allen, MD

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